A Case of Localized Malignant Peritoneal Mesothelioma Evaluated by 18F-FDG PET/CT

Xu, Tingting; Hu, Jiajia; Zhang, Xinyi; Cao, Jianpeng; Chen, Yue

doi:10.1097/rlu.0000000000003158

Cited by 3 publications

(13 citation statements)

References 11 publications

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“…This study confirms that LMPeM in women is indeed a rare tumor as the 18 cases presented herein were collected in a large tertiary oncologic center over a 43-year period. This is in concordance with the English literature where 43 of such cases have been reported in a span of 26 years (1995 to 2021) 1–22,28,29. The mean and median ages were slightly higher than that reported in the literature (57 and 55 y, respectively, vs. 53.7 and 54 y, respectively) 1–22,28,29.…”

Section: Discussionsupporting

confidence: 90%

“…This is in concordance with the English literature where 43 of such cases have been reported in a span of 26 years (1995 to 2021) 1–22,28,29. The mean and median ages were slightly higher than that reported in the literature (57 and 55 y, respectively, vs. 53.7 and 54 y, respectively) 1–22,28,29. This study presents for the first time the ethnic distribution of women affected by LMPeM who were mostly Caucasians (80%), followed by African Americans (13%) and Hispanics (7%).…”

Section: Discussionsupporting

confidence: 89%

“…The mean OS of our patients was 80.4 months, which is lower than the 100.67 months (95% confidence interval: 80.52-140.83) for the cases in the literature. The 3-year OS of our cases was better than reported in the literature (79% vs. 74.9%), while the 5-year OS in this study was worse than in other studies (52.6% vs. 65.6%) 1,5–9,12,15–19,21,28–30…”

Section: Discussioncontrasting

confidence: 66%

“…Localized malignant peritoneal mesothelioma (LMPeM) in women is a rare neoplasm with <50 cases reported in the English literature since 1995. Because of the rarity of this tumor and the succinctness of most reports, the amount of information available on this disease is limited 1–23. The purpose of this clinicopathologic study is to present our experience with 18 cases of LMPeM in women, the largest cohort of this entity published thus far.…”

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confidence: 99%

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Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

Malpica¹,

Euscher²,

Marques‐Piubelli

et al. 2022

American Journal of Surgical Pathology

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Localized malignant peritoneal mesothelioma is a rare tumor with limited information in the literature. In this study, we present our experience with 18 cases seen in our hospital over a period of 43 years (1978 to 2021). Patients' median age was 55 years (y) (range: 33 to 79 y) and most of them were Caucasians. Patients presented with abdominal pain (11), ascites and right leg swelling (1), abdominal mass (1), and as incidental finding (1). Thirty percent of patients reported asbestos exposure, and all patients with available information had family history of tumors; a third had personal history of tumors. Seventy-seven percent had some form of abdominopelvic surgery and/or inflammatory process. Most cases had microscopic features typically seen in malignant mesothelioma; however, some cases had confounding features such as signet-ring cells, spindle cells, clear cell changes, and adenomatoid tumor-like appearance. BAP-1 by immunohistochemistry was lost in 1/3 cases. Only 1 patient underwent genetic testing and had an MSH2 germline mutation. Homozygous deletion of CDKN2A by FISH was not found in 1 tested case, although next-generation sequencing identified a CDKN2A pathogenic mutation. 16/18 (88%) had surgical treatment, and some also received adjuvant chemotherapy. The mean overall survival (OS) of our patients was 80.4 months (95% confidence interval: 54.3-106.52); the 3-year OS was 79%, while the 5-year OS was 52.6%. Fifty-three percent of patients had recurrences and 20% had tumor progression. Although the limited sample precludes definitive conclusions, small tumor size, low-grade cytology, and low mitotic index appeared to be associated with an indolent behavior.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 66%

mentioning

confidence: 99%

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Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

Malpica¹,

Euscher²,

Marques‐Piubelli

et al. 2022

American Journal of Surgical Pathology

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“…5 In pleural and peritoneal mesothelioma, 18 F-FDG PET/CT is a metabolic imaging modality used for staging, restaging, and treatment response assessment. [6][7][8][9][10][11][12] This case presents the rarity of primary mesothelioma of the liver. Furthermore, we highlight the value of 18 F-FDG PET/CT in diagnosing and staging primary hepatic mesothelioma by ruling out a possible malignant primary tumor from elsewhere in the body and detecting lymph node metastases.…”

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18F-FDG PET/CT in Primary Mesothelioma of the Liver

et al. 2022

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Primary malignant mesothelioma is a rarity among malignant liver tumors. We present the case of a 48-year-old woman presenting with increasing upper abdominal discomfort and inappetence accompanied by a weight loss of approximately 10 kg. CT and MRI revealed a highly suspicious mass lesion in the liver. 18 F-FDG PET/CT performed for staging showed a pathological 18 F-FDG uptake of the known liver tumor. Histology and immunohistochemistry indicated mesothelioma of the liver. Herein we present a rare case of primary mesothelioma in the liver with CT, MRI, and 18 F-FDG PET/CT.

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Malignant Peritoneal Mesothelioma Features Shown by FDG-PET/CT

Kuribayashi¹,

Kitajima

Minami³

et al. 2022

CDP

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Background/Aim: Malignant peritoneal meso-thelioma (MPeM) has no specific imaging findings that can distinguish it from other peritoneal tumors and the accuracy of peritoneal cytology is low, therefore definitive diagnosis is usually performed by histology. This study investigated whether 18F-fluorodeoxyglucose positron emission tomography/ computed tomography representing glucose metabolism is a useful modality for identifying biopsy sites using the tumor viability of MPeM. Patients and Methods: Sixty MPeM patients underwent pre-biopsy FDG-PET/CT examination. The findings were retrospectively evaluated, and histopathological subtype differences were investigated. Results: The diffuse MPeM type was found in 45 (75.0%) and the localized type in 15 (25.0%) cases. The most frequent site of occurrence was the peritoneum (91.7%), followed by the omentum (51.7%). FDG-avid results were noted in 55 patients (91.7%), while 5 (8.3%) showed no FDG uptake with a variety of maximum standardize uptake value (SUVmax) values (range=0-16.77, mean=7.32±4.05). In the 53 epithelial cases, mean SUVmax (7.09±4.07, range=0-16.77) was slightly lower compared to the 4 biphasic (8.30±4.70, range=2.35-13.36) and 3 sarcomatoid (10.08±2.64, range=8.21-13.10) cases, without any significant difference (p=0.12). Diffuse and focal disease patterns showed similar percentages in the three types. Six cases (10.0%) had nodal metastases and 6 (10.0%) extra-abdominal metastases. Compared to the biphasic and sarcomatoid groups, nodal metastases were more common in the epithelial group, while extra-abdominal metastases were more often seen in the biphasic and sarcomatoid groups. Ascites was seen in 53 (83.3%), pleural effusion in 43 (71.7%), and pleural plaque in 31 (51.7%) cases. Conclusion: Through reviewing and elucidation of the FDG-PET/CT features of MPeM, it was shown that FDG-PET/CT is an extremely useful modality for identifying biopsy sites of MPeM.

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A Case of Localized Malignant Peritoneal Mesothelioma Evaluated by 18F-FDG PET/CT

Cited by 3 publications

References 11 publications

Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases

18F-FDG PET/CT in Primary Mesothelioma of the Liver

Malignant Peritoneal Mesothelioma Features Shown by FDG-PET/CT

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