A Case of Metastatic Bladder Cancer in Both Lungs Treated with Korean Medicine Therapy Alone

Lee, Dong-Hyun; Kim, Sung‐Su; Seong, Sin; Woo, Chang-Ryoul; Yu, Hyejin; Cho, Wonjun

doi:10.1016/j.imr.2015.04.173

Cited by 4 publications

(6 citation statements)

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“…In this way, AP‐1 protects normal cell viability against Frankincense cytotoxicity and apoptotic effects on cancerous cells (Dozmorov et al, 2014). Anticancer activity of Frankincense on bladder cancer has also been presented in two case reports (Lee et al, 2014). One of these reports is about a man who elected the daily administration of Boswellia Sacra gum resin with lifestyle change following the transurethral resection of bladder tumor (TURBT) instead of standard therapy (Xia et al, 2017).…”

Section: Bladder Cancermentioning

confidence: 76%

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Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Khajehdehi

Khalaj‐Kondori

Baradaran

2022

Phytotherapy Research

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Chemical diversity of natural products with drug-like features has attracted much attention from medicine to develop more safe and effective drugs. Their anti-inflammatory, antitumor, analgesic, and other therapeutic properties are sometimes more successful than chemical drugs in controlling disease due to fewer drug resistance and side effects and being more tolerable in a long time. Frankincense, the oleo gum resin extracted from the Boswellia species, contains some of these chemicals. The anti-inflammatory effect of its main ingredient, boswellic acid, has been traditionally used to treat many diseases, mainly those target memory functions. In this review, we have accumulated research evidence from the beneficial effect of Frankincense consumption in memory improvement and the prevention of inflammation and cancer. Besides, we have discussed the molecular pathways mediating the therapeutic effects of this natural supplement.

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Section: Bladder Cancermentioning

confidence: 76%

“…The other report is related to a metastatic bladder cancer treated by Korean medicine therapy (KMT), including Boswellia carteri and other herbals (Lee et al, 2014). The decrease in size and number of metastatic nodules in both lungs and symptoms disappearance resulted from this remedy (Lee et al, 2014).…”

Section: Bladder Cancermentioning

confidence: 99%

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Khajehdehi

Khalaj‐Kondori

Baradaran

2022

Phytotherapy Research

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“…Additionally, boswellic acids possess in vivo anticancer effects toward the following various cancers viz., colon cancer [20], Ehrlich tumor [21], colorectal cancer [11], glioma [14], leukemia [22], pancreatic cancer [15] and prostate cancer [19]. Most importantly, some clinical studies have also been reported in which boswellic acids have been successfully used for cancer treatment viz., brain tumor, lung cancer, and breast cancer [23][24][25][26][27]. Although only a few reviews have been published on the biological effects of boswellic acids [6,[28][29][30][31][32][33][34], in this review, we provide an historical background of the structural elucidation and cytotoxic effects of the most active boswellic acid synthetic derivatives (IC 50 : ≤10 µM or percentage inhibition >90%).…”

Section: Introductionmentioning

confidence: 99%

Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery

Hussain

Ali

Hakkim

et al. 2021

Expert Opinion on Drug Discovery

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Introduction: Cancer has been identified to be the second major cause of death internationally as exemplified by ca. 9.6 million deaths in 2018 along with ca. 18 million new patients in 2018 that have been recorded. Natural boswellic acids (BAs) and their source, frankincense, have been reported to possess in vitro and in vivo anticancer effects toward various cancer cells. Areas covered: This comprehensive review focuses on the importance of boswellic acids (BAs) for the establishment of future treatments of cancer. Moreover, potent semisynthetic derivatives of BAs have been described along with their mode of action. In addition, important structural features of the semisynthetic BAs required for cytotoxic effects are also discussed. Expert opinion: Numerous semisynthetic BAs illustrate excellent cytotoxic effects. Of note, compounds bearing cyanoenone moieties in ring A, endoperoxides and hybrids display increased and more potent cytotoxic effects compared with other semisynthetic BAs. Moreover, BAs have the potential to conjugate or couple with other anticancer compounds to synergistically increase their combined anticancer effects. In addition, to get derived BAs to become lead anticancer compounds, future research should focus on the preparation of ring A cyanoenones, endoperoxides, and C-24 amide analogs.

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“…37) Soramdan is composed of wild ginseng. 90) Previous studies reported that wild ginseng showed anticancer effect in the human lung cancer cell line 38) and in patients with lung cancer relatively. 39) The cases analyzed in this study are the instances of applying these experimental research in clinics based on effective results -which is significant in that the experimental studies indeed reach out to clinics for clinical verification.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Case Reports about Korean Medicine for Lung Cancer

et al. 2018

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This systematic review aimed to put the case reports of lung cancer on Korean medicine (KM) together and adopt the results in clinical practice. Methods: Researches were searched using the PubMed, EMBASE, OASIS, KoreanTK, KISTI, RISS, KISS, and NDSL. The search term were 'lung cancer' and KM. There was no restriction in year. Results: 1. Among the 48 studies, 68 patients were reported in total. The types of lung cancer were non-small-cell lung cancer (n=41) and small-cell lung cancer (n=6). 2. The number of patients who received KM therapy alone was 40. On the other hand, 25 patients were treated with KM and chemotherapy simultaneously. All case reports used herbal medicine except 2 studies. Other types of treatment were acupuncture, moxibustion, pharmacopuncture, cupping, meditation, etc. 3. Several efficacy evaluation variables were used such as tumor size, changes of symptoms, duration of survival, the quality of life, and so on. The safety was evaluated by checking adverse effects using blood test. 4. Regarding the tumor response, partial response was reported in 12 cases, stable disease was in 22 cases, 50% of the total cases, which is a high level of tumor response. Furthermore, all 11 cases with the evaluation on the length of survival showed prolonged survival than the expectancy of corresponding stage, with the stable quality of life. Conclusion: We have found that the applicability of KM for treatment of lung cancer through this review. Evidence based medicine can be realized by checking cases and applying them in clinical practice.

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A Case of Metastatic Bladder Cancer in Both Lungs Treated with Korean Medicine Therapy Alone

Cited by 4 publications

References 0 publications

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery

Systematic Review of Case Reports about Korean Medicine for Lung Cancer

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