A Case of Micronodular Thymic Carcinoma with Lymphoid Stroma

Kadomatsu, Yuka; Nakashima, Kiyoshi; Ueno, H.; Okasaka, Toshiki; Mori, Satoshi

doi:10.2482/haigan.55.59

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extracted patient data included patient age, sex, surgical procedure, Masaoka stage, 1 TNM stage based on the TNM Classification of Malignant Tumours 8th Edition of the UICC , 12 and clinical outcomes. The clinical courses of two cases (Cases 2 and 11) were previously published as case reports 13,14 …”

Section: Methodsmentioning

confidence: 99%

“…The clinical courses of two cases (Cases 2 and 11) were previously published as case reports. 13 , 14 …”

Section: Methodsmentioning

confidence: 99%

“…The clinical courses of two cases (Cases 2 and 11) were previously published as case reports. 13,14 This study was conducted in accordance with the recommendations of the Declaration of Helsinki and was approved by the ethics committees of the participating hospitals.…”

Section: Patients and Tissue Specimensmentioning

confidence: 99%

See 2 more Smart Citations

Difference in the distribution of tumor‐infiltrating CD8+ T cells and FOXP3+ T cells between micronodular thymoma with lymphoid stroma and micronodular thymic carcinoma with lymphoid stroma

Yagi

Nakaguro

Ito³

et al. 2021

Pathology International

View full text Add to dashboard Cite

Micronodular thymoma with lymphoid stroma (MNT) is a rare thymic epithelial neoplasm subtype characterized by a micronodular tumor cell growth pattern and abundant lymphoid stroma. Micronodular thymic carcinoma with lymphoid stroma (MNCA) is considered as a malignant counterpart of MNT and exhibits a growth pattern similar to that of MNT but has histologic features reminiscent of thymic squamous cell carcinoma, such as cytologic atypia and CD5 and CD117 immunoexpression. Although both MNT and MNCA are characterized by abundant lymphoid stroma, it remains unknown whether there are differences in infiltrating lymphocytes between MNT and MNCA. We analyzed the immune microenvironment profile in eight MNT and three MNCA cases. The cell density of CD8-positive T cells was significantly higher in MNT than in MNCA, whereas that of FOXP3-positive T cells was significantly higher in MNCA than in MNT. There was no significant difference in the cell density of programmed death protein 1-positive T cells and programmed death ligand 1 expression between the MNT and MNCA cases. Our findings indicated that the immune microenvironment of MNCA differed from that of MNT and, compared with the T-cell profile of MNT, that of MNCA was more suppressive to patients′ antitumor immune response.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The clinical courses of two cases (Cases 2 and 11) were previously published as case reports. 13 , 14 …”

Section: Methodsmentioning

confidence: 99%