A case of multiple gastric adenocarcinomas of fundic gland type

Watanabe, Ryoji; Yada, Tomoyuki; Ikegami, Yurika; Ito, Koichi; Itakura, Yoshiyuki; Koizuka, Hitohiko; Uemura, Naomi

doi:10.11641/pde.92.1_104

Cited by 2 publications

(3 citation statements)

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“…In multiple cases, Kino et al[13] reported that the patients with two lesions had received Helicobacter pylori eradication therapy and that the atrophy of the gastric mucosa had improved. Watanabe et al[14] reported that a patient with three lesions was not infected with Helicobacter pylori and that the gastric mucosa was not atrophic. Chiba et al[6] reported that among 20 patients, 15 (75%) cases were of the closed type or open type atrophic gastritis.…”

Section: Discussionmentioning

confidence: 99%

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Multiple gastric adenocarcinoma of fundic gland type: A case report

Chen¹,

Shao²,

Qiu³

et al. 2019

WJCC

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BACKGROUNDIn recent years, there have been reports of a new histological type of gastric cancer, termed gastric adenocarcinoma of the fundic gland (GA-FG). This disease entity presents differentiation towards the fundic gland, especially chief cell-predominant differentiation (GA-FG-CCP). GA-FG-CCP easily invades into the submucosa but rarely shows metastasis. The reports mostly describe primarily single lesions. Herein, we report a case with multiple lesions, and summarize the clinicopathologic characteristics of multiple cases.CASE SUMMARYA 55-year-old woman underwent upper gastrointestinal endoscopy screening. Two whitish lesions on the anterior wall of the gastric corpus and the gastric fundus were detected. The patient had previously received Helicobacter pylori eradication therapy. The mucosa was characterized as grade C-2 atrophic gastritis. We diagnosed the patient with multiple GA-FG (GA-FG-CCP) by hematoxylin and eosin (HE) staining and immunohistochemical staining of the endoscopic biopsy. Upon performing endoscopic submucosal dissection (ESD), one lesion was not found, but the scar from the biopsy was visible; the mucularis mucosa of the biopsy and ESD-resected specimen were intact. The two lesions showed no lymphatic nor venous invasion. The resection performed appeared to be relatively curative.CONCLUSIONCases of multiple GA-FG-CCP are very rare in clinical practice. Most of its clinicopathologic characteristics are similar to those of a single lesion. Our case provides diagnostic and therapeutic information about GA-FG-CCP with multiple lesions.

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Section: Discussionmentioning

confidence: 99%

“…Regarding cases with multiple lesions, the depth of infiltration of our two lesions were limited to the mucosal layer. Watanabe et al[14] reported that the three lesions had infiltrated into the submucosa; the infiltration depths were 200 μm, 11 μm, and 38 μm; the resection they performed was also thought to be curative.…”

Section: Discussionmentioning

confidence: 99%

Multiple gastric adenocarcinoma of fundic gland type: A case report

Chen¹,

Shao²,

Qiu³

et al. 2019

WJCC

View full text Add to dashboard Cite

show abstract

“…It originates from the deep part of normal fundic glands without atrophy 2 . Most are solitary lesions; only three cases of multiple lesions have been reported thus far 3 4 5 . To the best of our knowledge, this is the first case of multiple such lesions located close enough to be endoscopically resected en masse.…”

Section: Endoscopy E-videosmentioning

confidence: 99%