A Case of Multiple Nevoid Hypertrichosis

Abstract

Nevoid hypertrichosis is an uncommon congenital disorder consisting of terminal hair growth in a localized distribution on flesh-colored skin; it is not associated with any other systemic abnormalities. A 21-year-old male patient had a circumscribed area of depigmented terminal hairs on his chest which had been present since 1 year of age. At the age of 18, similar lesions developed on his left shoulder and upper arm. The underlying skin was slightly hypopigmented, and no other systemic abnormalities were found. Histologic examination demonstrated terminal hair follicles in otherwise normal skin. The number of HMB 45 positive melanocytes was markedly decreased in the affected skin. This case of multiple nevoid hypertrichosis is reported with a review of previously reported cases.

Nevoid hypertrichosis: Case report with review of the literature

“…[3] A few cases of multiple NH in which patches are either round, in a check-board or linear pattern, along Blaschko's lines have also been documented. [2] The color of the terminal hair may be the same as the color of the scalp hair, rarely grey or white. [124] The histopathology usually shows a normal epidermis with increased number of morphologically normal hair follicles in the dermis but is needed to rule out any underlying nevus.…”

“…Nevoid hypertrichosis (NH) is an uncommon disorder consisting of a solitary, circumscribed area of terminal hair growth present at or soon after birth. [12] The involved hair may be normal or hypo-pigmented, with or without any associated cutaneous and extra-cutaneous abnormalities. [2] We report a 12- year- old boy with localized hypertrichosis but without any underlying pigmentary or structural abnormality.…”

Nevoid hypertrichosis in a pre-adolescent girl

“…Mostly, it presents at or soon after birth;[1] although, uncommonly, it may present at a later age (around puberty). [2] The lesion is known to remain stable, with any increase in size being proportional to the growth of the child. It tends to persist, although spontaneous resolution has rarely been reported.…”

“…[3] It is usually localized in the form of solitary or multiple patches. [2] Variable distribution patterns such as Blaschkoid, linear, segmental, or checkerboard patterns have been reported. There are no specific sites of predilection.…”

“…The color of the lesional hair is the same as the scalp hair; however, reports exist of depigmented hair as well as premature graying of hair in the patch. [2] The condition is often not associated with an underlying musculoskeletal, central nervous system, or ocular abnormality.…”