A case of papillary and infiltrative urothelial carcinoma of the urinary bladder in a terrier dog

Abstract

Urothelial carcinoma are malignant tumours originating from the epithelial layer of the urinary bladder. In this instance, a case of infiltrative type urothelial carcinoma in the urinary bladder of a 2-year-old terrier dog was defined histopathologically and immunohistochemically. The material of the presented case consisted of urinary bladder tissue samples that were surgically extirpated from a two-year-old terrier-breed female dog that applied to the Department of Surgery of the Faculty of Veterinary Medicine, Selcuk University with the complaint of hematuria. The tumour brought to the pathology laboratory was 11*10*12 cm in size and had finger-shaped extensions. Its outer surface was rough and hemorrhagic. Tissues were fixed in 10% buffered formalin and paraffin blocks were obtained by going through the necessary routine follow-up procedures. Afterwards, sections were taken and subjected to Hematoxylin-Eosin, Masson's Trichrome and immunohistochemical staining. As a result of the pathological and immunohistochemical examinations of the tumoral tissue samples taken from the urinary bladder of a two-year-old terrier dog, the diagnosis of infiltrative type urothelial carcinoma was reached, and the case was discussed with the information provided by the literature. In addition, immunohistochemically, intense PCNA and VEGF staining has been associated with malignancy.