A case of paraquat intoxication caused by intravenous injection

Choi, Yoonhee; Cho, Kwang-Hyun; Yoon, Soon-Young; Lee, Hyungmin; Choi, Yu Hyeon

doi:10.1016/j.ajem.2007.12.016

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…Severe PQ poisoning is characterized by multiple-organ failure, which mainly involves the lungs, kidneys, liver, heart and also the nervous system. The lung is a major target organ in paraquat poisoning, and respiratory failure from lung injury is the most common cause of death [3] [4]. The exact mechanism of PQ poisoning is currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Using Bosentan to Treat Paraquat Poisoning-Induced Acute Lung Injury in Rats

et al. 2013

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BackgroundParaquat poisoning is well known for causing multiple organ function failure (MODS) and high mortality. Acute lung injury and advanced pulmonary fibrosis are the most serious complications. Bosentan is a dual endothelin receptor antagonist. It plays an important role in treating PF. There is no related literature on the use of bosentan therapy for paraquat poisoning.ObjectiveTo study the use of bosentan to treat acute lung injury and pulmonary fibrosis as induced by paraquat.MethodA total of 120 adult Wister male rats were randomly assigned to three groups: the paraquat poisoning group (rats were intragastrically administered with paraquat at 50 mg/kg body weight once at the beginning); the bosentan therapy group (rats were administered bosentan at 100 mg/kg body weight by intragastric administration half an hour after paraquat was administered, then the same dose was administered once a day); and a control group (rats were administered intragastric physiological saline). On the 3rd, 7th, 14th, and 21st days following paraquat exposure, rats were sacrificed, and samples of lung tissue and venous blood were collected. The levels of transforming growth factor-β1 (TGF-β1), endothelin-1 (ET-1), and hydroxyproline (HYP) in the plasma and lung homogenate were determined. Optical and electronic microscopes were used to examine pathological changes.ResultThe TGF-β1, ET-1, and HYP of the paraquat poisoning group were significantly higher than in the control group, and they were significantly lower in the 21st day therapy group than in the paraquat poisoning group on the same day. Under the optical and electronic microscopes, lung tissue damage was observed to be more severe but was then reduced after bosentan was administered.ConclusionBosentan can reduce inflammation factor release. It has a therapeutic effect on acute lung injury as induced by paraquat.

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Section: Introductionmentioning

confidence: 99%

Using Bosentan to Treat Paraquat Poisoning-Induced Acute Lung Injury in Rats

et al. 2013

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“…Laboratory testing includes urine testing that detects paraquat concentrations of 1 mg/mL or above, gas chromatography (1 microgram/mL) and radioimmunoassay (< 0.1 microgram/mL). When comparing exposure modes, the least to most fatal forms of exposure are: inhalation, ingestion, and intravenous exposure [3][4][5].…”

Section: Discussion: Clinical Coursementioning

confidence: 99%

Paraquat Poisoning: Survival after Oral Ingestion

Sarah¹,

Mario²,

Alice³

et al. 2019

J Fam Med Dis Prev

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“…İdrar ve kanda parakuat için kalitatif ve kantitatif analiz tanıda yardımcı olabilir. Seri solunum fonksiyon testleri, akciğer grafisi ve alveoler-arteriyel gradient içeren arteryel kan gazı tayini zehirlenmede izlem için kullanılabilir (1,8). Tüm zehirlenmelerde olduğu gibi hikaye tanıda son derece önemlidir.…”

Section: Discussionunclassified

“…Kömür hemoperfüzyonu parakuatı temizleyebilir, mümkün olduğu en kısa zamanda alınmalıdır ve 6-8 saat devam edilmelidir (3,8). Biz de hastamıza tekrarlayan aktif kömür, mide lavajı, sıvı replasmanı, intarvenöz steroid tedavisi ve kömürsüz hemoperfüzyon tedavisi uygulandık.…”

Section: Discussionunclassified

Paraquat intoxication: a case report

Eraybar¹,

Köse²,

Özdemir³

et al. 2011

Gaziantep Med J

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ÖzetZararlı bitkileri öldürmek amacıyla (herbisit) yaygın olarak kullanılan parakuat insanlarda da kazara ya da intihar amaçlı kullanıldığında yüksek oranda morbidite ve mortaliteye neden olmaktadır. İntihar amaçlı yüksek miktarda parakuat alım öyküsü sonrasında başlangıçta asemptomatik olup takiplerinde gastrointestinal, böbrek ve karaciğer etkilenmesi gelişen ve acil serviste takip ve tedavisi yapılan 23 yaşında genç bayan olguyu sunmaktayız. Ciddi parakuat zehirlenmesi olan hastalar alımından sonra asemptomatik olabilir, ancak birkaç saat içinde hızla bozulabilir. Bu nedenle parakuat alımlarında asemptomatik olsa bile hasta karaciğer, böbrek ve akciğer etkileri açısından uzun süre takip edilmelidir. Anahtar kelimeler: Çoklu organ yetmezliği; parakuat; zehirlenme Abstract Paraquat, a widely used herbicide, causes high morbidity and mortality in people when taken accidentally or for suicidal intent. In this study our aim is to present the treatment and follow up of a 23 years old young lady after a history of suicide attempt in the emergency department after taking large amount of paraquat. The patient was initially asymptomatic and in follow up care gastrointestinal, renal and liver toxicity developed. Patients with severe paraquat poisoning may be asymptomatic after ingestion, but may deteriorate rapidly within a few hours. Therefore, in the case of taking high dose paraquat, the patient needs long term follow up for liver, kidney and lung effects even if he is asymptomatic.

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A case of paraquat intoxication caused by intravenous injection

Cited by 14 publications

References 9 publications

Using Bosentan to Treat Paraquat Poisoning-Induced Acute Lung Injury in Rats

Using Bosentan to Treat Paraquat Poisoning-Induced Acute Lung Injury in Rats

Paraquat Poisoning: Survival after Oral Ingestion

Paraquat intoxication: a case report

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