A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer

Piras, Marta; Panebianco, Martina; Garibaldi, Matteo; Roberto, Michela; Merlonghi, Gioia; Pellegrini, Patrizia; Marchetti, Paolo

doi:10.3390/curroncol28030182

Cited by 4 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 After Dr. Piras et al gave both neoadjuvant and DM-related treatment, the patient's DM symptoms had largely recovered, mastectomy was performed, and the patient recovered well. 10 Controlling DMrelated symptoms before surgery reduces postoperative wound healing from DM, but the overall time to control the disease is longer than patients treated surgically first. Some clinicians believe it is critical to address tumor-related issues first, as DM may manifest as a paraneoplastic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“… 8 , 9 According to epidemiological statistics, 15–30% of cases of DM are associated with malignancies. 10 A study from Asia showed that DM is the second most common disease associated with breast cancer in women. 11 There are no treatment guidelines related for breast cancer associated with DM, and individualized treatment is based on the clinical cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Triple-Negative Breast Cancer with Dermatomyositis: A Case Report and Literature Review

Chen

Liu

et al. 2022

CMAR

View full text Add to dashboard Cite

Dermatomyositis (DM) is an autoimmune inflammatory myopathy, the onset of which is sometimes associated with some malignancies and sometimes appears as a symptom of paraneoplastic syndrome. The main symptoms include progressive proximal muscle weakness, extra muscular manifestations such as dyspnea or dysphagia, and skin changes. There is currently no standardized treatment for breast cancer associated with DM. Patients and Methods: We report a 45-year-old woman with a palpable mass over the left external breast along with diffuse erythema on the shoulder, orbital edema, voice hoarseness, dyspnea, and weakness of the extremities. Needle aspiration biopsy and imaging suggested malignancy. Thus, breast-conserving surgery and pectoral myotomy biopsy+ skin excision biopsy were performed. Pathology confirmed triple-negative breast cancer (TNBC) and DM. Two days after surgery, the patient's orbital edema, voice hoarseness, dyspnea, and weakness of the extremities were significantly reduced, and the erythema subsided significantly. Left axillary lymph node dissection was performed after postoperative adjuvant chemotherapy, and the nodes were negative. The patient was recovering well, and follow-up showed no signs of recurrence or metastasis. Conclusion: Be alert for the presence of malignancy when a breast cancer patient presents with DM, a test for dermatologists, rheumatologists, and oncologists. This case demonstrated the effectiveness of breast-conserving surgery combined with radiotherapy for early-stage triple-negative breast cancer with DM, even without further treatment for DM to reduce the symptoms. In conclusion, the treatment plan for these patients depends on the presentation of the tumor and DM.

show abstract

Section: Discussionmentioning

confidence: 99%