A Case of Pleomorphic Liposarcoma Originating from Mesentery

Abstract

Liposarcoma is one of the most common soft tissue sarcomas that occurs in adults and is currently divided into five main subgroups: well-differentiated, myxoid, round cell, pleomorphic, and dedifferentiated. Primary mesenteric liposarcoma is extremely rare, and the treatment strategy is surgical resection with a wide free margin, often followed by radiation and adjuvant chemotherapy if distant metastasis is not detected. A 73-year-old male patient presented with lower abdominal distension. Abdominal CT scan revealed a large homogeneously enhancing mass lesion abutting the sigmoid colon and urinary bladder. At laparotomy, the solid mass measured 28×26×12 cm in size, was well-demarcated, and originated from the mesentery of the middle ileum. It was removed along with some small intestine (ileocecal valve upper 50-150 cm) and ileal mesentery because of adhesion. Histologically, the tumor proved to be pleomorphic liposarcoma. The patient did not undergo any adjuvant treatment following surgery, but he remains disease free until 33 months after surgery. Herein, we report a case of pleomorphic liposarcoma arising from small bowel mesentery.

The colorectal surgeon's liposarcoma

“…Garg et al 6 reported two cases and identified only 22 others in the literature; an additional eight cases have since been reported making a total of only 31 reported cases of mesenteric liposarcoma. [7][8][9] Of these, there have been only two previously reported cases of mesenteric liposarcoma affecting the sigmoid mesocolon both of which were dedifferentiated liposarcoma. As such, our patient's liposarcoma is the first reported WDLPS of the sigmoid mesocolon.…”

“…2,5 Liposarcoma of the intestinal mesentery is a rare occurrence. [7][8][9] Of these, there have been only two previously reported cases of mesenteric liposarcoma affecting the sigmoid mesocolon both of which were dedifferentiated liposarcoma. [7][8][9] Of these, there have been only two previously reported cases of mesenteric liposarcoma affecting the sigmoid mesocolon both of which were dedifferentiated liposarcoma.…”

Rare Pleomorphic Liposarcoma Presented as Jejunal Obstruction

“…About 50% of PLS were found in the lower extremities, followed by upper extremities, axilla, head and neck, and chest region [2][3][4]. PLS arising in the gastrointestinal (GI) tract is extremely rare with only a handful of cases reported in the literature [5][6][7][8].…”

Dedifferentiated liposarcoma with a rare presentation of disseminated intraperitoneal sarcomatosis: A case report

“…Most dedifferentiated liposarcomas arise de-novo as primary tumors, with a minority presenting as recurrences of well-differentiated liposarcomas [2]. Reports of liposarcomas arising primarily from intraperitoneal sites such as the omentum or mesentery are rare, with only 40 cases described in the literature [[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26]]. Of the 40 cases, 18 were of the dedifferentiated subtype, and all 40 presented with localized resectable disease.…”