A Case of Polypoid Clear Cell Acanthoma on the Nipple

Park, Se Young; Jung, Ji Ye; Na, Jung Im; Byun, Hee Jin; Cho, Kwang Hyun

doi:10.5021/ad.2010.22.3.337

Cited by 20 publications

(37 citation statements)

References 11 publications

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“…15 Supporting the inflammatory hypothesis, chronic inflammatory dermatoses, including atopic dermatitis, were found in association with CCA of the nipple area in almost all of the reported cases. 13 Histological as well as dermoscopic similarities to plaque-type psoriasis may strengthen such viewpoint. Furthermore, several researchers have favored CCA as an inflammatory/reactive process, given its associations, and even overlappings, with preexisting inflammatory dermatoses such as stasis dermatitis, bacterial infections, psoriatic plaques, and trauma.…”

Section: Discussionmentioning

confidence: 96%

“…12 A further case of a 14-year-old atopic Korean girl with a slow-growing, itchy, polypoid nodule on the left nipple was reported. 13 In addition to the cases with nipple/areola localization published to date, Kerl reported on a female patient with CCA on the right breast without specifying the area. 16 Lesions located on the sternum and costal archs were present in the case of a 52-year-old male with multiple lesions reported by Fandrey et al 9 Another case of pigmented CCA on the left upper chest of a 60-year-old Korean man whose original picture clearly shows proximity to the areola was reported by Choe et al 17 These cases as well as ours may suggest that the breast area, including the nipple/areola area, represents a site on which, although rarely, CCA may occur.…”

Section: Discussionmentioning

confidence: 99%

“…So far, these cases have only been observed in young Korean women, either mimicking a nipple eczema or presenting a polypoid growth pattern. 11,12,13 The aim of this article is to present the clinical, histopathological, and immunohistochemical features of two additional cases, which were observed in Brazilian women with a similar topography. …”

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confidence: 99%

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Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Veiga

Barros²,

Santos³

et al. 2013

An. Bras. Dermatol.

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Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, sometimes occurring in an eruptive fashion, and with clear variation in the size and shape of the cutaneous lesions have been reported. So far, five cases in which the lesions were exclusively located in the nipple area have been reported, all in Korean women. Four of these cases mimicked eczema and one, a polypoid nodule. The aim of this article is to present clinical, histopathological, and immunohistochemical features of two additional cases in Brazilian women with similar nipple topography.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Veiga

Barros²,

Santos³

et al. 2013

An. Bras. Dermatol.

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“…The exact pathogenesis of CCA is not understood. It was originally thought to be a benign epidermal tumour, but a more recent hypothesis, suggests that CCA is a reactive inflammatory dermatosis 6 . However, it remains unclear whether CCA is a benign tumour or an inflammatory disease 7,8 …”

Section: Pathogenesis and Aetiologymentioning

confidence: 99%

Clear cell acanthoma

Tempark

Shwayder

2012

Clinical and Experimental Dermatology

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SummaryClear cell acanthoma (CCA), is an asymptomatic benign lesion of unknown origin and aetiology, which typically presents as a red to brown, dome-shaped papule on the leg. We discuss the case of a patient with an irregular plaque of hypopigmented papules whose diagnosis of CCA was only made by biopsy, and review the characteristic presentation, uncommon variants, locations and associated conditions of this lesion. The diagnosis is based on histopathology and ⁄ or immunohistochemistry, but the variable clinical presentation may make diagnosis difficult. The differential diagnosis includes skin tumours and inflammatory and pigmentary dermatoses. The lesions do not regress spontaneously, and excisional removal is the preferred treatment.

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“…The rare diseases of the nipple namely 'polypoid clear cell Acanthoma' [10] and 'Fibroepithelial stromal polyp' [11] can be misdiagnosed for seborrheic keratosis. A meticulous clinical examination or rarely biopsy may be required to differentiate it from seborrheic keratosis.…”

mentioning

confidence: 99%

Seborrheic Keratosis of Male Breast: A Case Report of Skin Problem Rare at Breast Clinic

Sinha¹,

Barman²,

Sirka³

et al. 2017

J Clin Case Rep

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Seborrheic keratosis is a benign skin disease occurring mostly over the sun exposed areas of the body. This dermatological problem is rare in the region of nipple areola complex. Most of the breast surgeons are unaware of this disease. The authors are describing a rare surgical encounter where a provisional diagnosis of breast polyp was made. He was further investigated to rule out any underlying breast malignancy. Finally, excision biopsy revealed the diagnosis. A prior suspicion of this disease could have avoided the need for all these complex investigations.

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A Case of Polypoid Clear Cell Acanthoma on the Nipple

Cited by 20 publications

References 11 publications

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Clear cell acanthoma

Seborrheic Keratosis of Male Breast: A Case Report of Skin Problem Rare at Breast Clinic

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