A case of recurrent acute cholecystitis caused by Actinomyces odontolyticus, rare actinomycosis

Abstract

Backgrounds Actinomyces species are gram-positive, obligate anaerobic rods and are rare causes of cholecystitis. Because Actinomyces species are anaerobic bacteria, it is difficult for Actinomyces to survive in bile apart from A. naeslundii. We experienced a case of recurrent acute cholecystitis caused by A. odontolyticus. Case presentation A patient had been diagnosed with acute cholecystitis and treated one month before and after that, admitted to our hospital because of recurrent cholecystitis. Gram stain of the bile revealed gram-positive rods and gram-positive cocci. We found A. odontolyticus and MRSA in bile culture and MRSA in blood culture. We administered piperacillin-tazobactam and then changed it to ampicillin-sulbactam and vancomycin. The patient underwent laparoscopic cholecystectomy and was discharged safely. Conclusions To our knowledge, this is the first case of cholecystitis caused by A. odontolyticus. Cholecystitis caused by Actinomyces species is rare. In addition, we may overlook it with the low positivity of bile cultures of Actinomyces. Whenever the cholecystitis recurs without any obstruction of the biliary tract, we should search for the gram-positive rods hidden in the bile, such as A. odontolyticus, as the causative organism, even if the bile culture is negative.

Actinomyces spp. Prosthetic Vascular Graft Infection (PVGI): A Multicenter Case-Series and Narrative Review of the Literature

“…A. odontolyticus is a resident bacterium of the oral cavity (being the main responsible for tooth biofilm formation), pharynx, distal esophagus, and distal urinary tract [1,36]. This pathogen has been reported to cause orocervicofacial [37][38][39], laryngeal [40,41], thoracic [42,43], renal [44,45], and pelvic actinomycosis [46,47], infection of the penile shaft [4], peritonitis [48], cholecystitis [49], liver abscesses [50,51], chronic conjunctivitis [52], spinal and brain abscesses (including meningitis) [53][54][55], foot, finger, arm abscesses [56][57][58], and other soft tissues involvement, such as cutaneous abscesses [59,60], osteomyelitis [61,62], purulent pericarditis [63,64], endocarditis [65], and BSI [66][67][68][69]. Looking at implant-associated infections with the contribution of A. odontolyticus, besides PVGI caused by A. odontolyticus [10,14,16,17], reports exist on endocarditis related to implantable cardioverter defibrillator [70], IUCD-associated pelvic actinomycosis [71,…”

Colecistitis aguda perforada con bacteriemia por Actinomyces naeslundii

“…La infección de la vesícula biliar por Actinomyces spp se considera extremadamente rara, habiéndose descrito previamente 25 casos en la literatura [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] . En 8 casos fue identificada la especie A. naeslundii, mientras que el resto corresponden a las especies A. israelii, A. odontolyticus, o sin determinar.…”

Evaluation of the antiproliferative and oxidative effects of polymeric cryogels on the model eukaryotic yeast Saccharomyces cerevisiae

“…Therefore, S. cerevisiae cells have become a popular in vitro model to understand questions in eukaryotic cell biology studies including oxidative stress and its toxicological aspects [25][26][27]. On the other hand, this is an opportunistic microorganism that cause invasive fungal infections in immunocompromised patients [28][29][30] and frequently used in the evaluation of antifungal effects of several agents, drugs or materials [31][32][33][34]. So, our ndings are of importance for the evaluation of antifungal action mechanism of these materials.…”