A Case of Rhizopus Keratitis

Kumar, Mada Pradeep; Gabriel, Castano; G, Gutierrez-Roberts Marithe; Joel, Chandranesan Andrew Stevenson

doi:10.23937/2378-3656/1410224

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The severity of ocular infections is comparatively less than with systemic manifestations. [5][6][7][8][9][10][11][12][13] The first case report of Contact lens-associated Rhizopus sp was reported in 2016 by Warner et al The risk factor identified was poor hygiene associated with CL usage. 8 Our patient underwent Standard CXL, and BCL was applied as a routine protocol to help in epithelial healing but developed a corneal ulcer on the third postoperative day.…”

Section: Discussionmentioning

confidence: 99%

Immediate postoperative keratitis caused by Rhizopus species following standard CXL for keratoconus: A case report and literature review

Venugopal,

Ravindran

2024

European Journal of Ophthalmology

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Purpose To report the first case of Rhizopus sp keratitis in a 15-year-old male patient who had undergone a conventional Epi-off CXL procedure for progressive keratoconus. Methods A 15-year-old male studying at school presented with defective vision in both eyes recently. He was diagnosed with progressive keratoconus in the right eye more than left eye. After the conventional CXL procedure, the patient developed corneal ulcer on third postoperative day. Results The microbiological diagnosis of both BCL and ulcer revealed Rhizopus sp. The patient responded to topical antifungals, and the ulcer entirely healed with a large central scar. Conclusion Rhizopus keratitis is rare in a healthy individual. Ours is the first case report of Rhizopus keratitis in patient undergone CXL.

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Section: Discussionmentioning

confidence: 99%

Immediate postoperative keratitis caused by Rhizopus species following standard CXL for keratoconus: A case report and literature review

Venugopal,

Ravindran

2024

European Journal of Ophthalmology

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“…Another azole demonstrating promise in the treatment of AK was found in one in vitro study, which found that isavuconazole was able to kill trophozoites within 24 h and prevented the transformation of inactive Acanthamoeba cysts into their active trophozoite forms [88]. While one case report has demonstrated its clinical effectiveness, there are no additional data evaluating its corneal penetration or clinical efficacy [97].…”

Section: Antimicrobial Agentsmentioning

confidence: 99%

New Frontiers in Acanthamoeba Keratitis Diagnosis and Management

Shareef,

Saeed

2023

Biology

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Acanthamoeba Keratitis (AK) is a severe corneal infection caused by the Acanthamoeba species of protozoa, potentially leading to permanent vision loss. AK requires prompt diagnosis and treatment to mitigate vision impairment. Diagnosing AK is challenging due to overlapping symptoms with other corneal infections, and treatment is made complicated by the organism’s dual forms and increasing virulence, and delayed diagnosis. In this review, new approaches in AK diagnostics and treatment within the last 5 years are discussed. The English-language literature on PubMed was reviewed using the search terms “Acanthamoeba keratitis” and “diagnosis” or “treatment” and focused on studies published between 2018 and 2023. Two hundred sixty-five publications were initially identified, of which eighty-seven met inclusion and exclusion criteria. This review highlights the findings of these studies. Notably, advances in PCR-based diagnostics may be clinically implemented in the near future, while antibody-based and machine-learning approaches hold promise for the future. Single-drug topical therapy (0.08% PHMB) may improve drug access and efficacy, while oral medication (i.e., miltefosine) may offer a treatment option for patients with recalcitrant disease.

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A Case of Rhizopus Keratitis

Cited by 2 publications

References 11 publications

Immediate postoperative keratitis caused by Rhizopus species following standard CXL for keratoconus: A case report and literature review

Immediate postoperative keratitis caused by Rhizopus species following standard CXL for keratoconus: A case report and literature review

New Frontiers in Acanthamoeba Keratitis Diagnosis and Management

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