A case of sickle-cell erythrocytosis occurring following renal transplantation

Abstract

We present an unusual case of post-renal transplant 'erythrocytosis' in a patient with sickle-cell anaemia, who had developed renal failure following the effects of a phaeochromocytoma. Prior to transplantation, the patient had experienced only occasional crises. However, post-transplant, he experienced multiple and varied crises, associated with a significant increase in haemoglobin concentration. These symptoms were partially alleviated by regular venesection.

EPAS1‐mutated paragangliomas associated with haemoglobin disorders

“…In sickle haemoglobinopathy carriers, PGL could be considered as a new rare tumoral complication in addition to previously reported renal medullary carcinomas. 18 Several cases of pheochromocytoma or PGL have previously been reported in patients with SCD, 15,[19][20][21][22][23] carry an EPAS1 somatic mutation. 24 This study being based on a population of patients affected by PPGL and not on a SCD population, it does not allow to analyse the relative risk for a haemoglobinopathy patient to develop PPGL and this should be the aim of subsequent studies.…”

Triple-way therapeutic approach for paraganglioma-dependent erythrocytosis: drugs and surgery plus “multi-manner” apheresis

“…Conditions such as renal cell carcinoma, hepatocellular carcinoma, rarely cerebellar hemangioblastoma, uterine fibromyoma, hypoxic lung disease, and cyanotic congenital heart diseases can be the cause of erythrocytosis, following hemorheological irregularity [6,19]. In addition, CHVS could be associated with cystic kidneys, renal artery stenosis, or renal transplantation [15,[20][21][22].…”