A case of squamous cell carcinoma of lung presenting with paraneoplastic type of acanthosis nigricans

Abstract

A 70-years-old male presented with blackening of both hands and face for last six months which was progressive and attended dermatology outpatients department. Dermatologist opined the skin lesions as acanthosis nigricans. He was referred to our department to evaluate for any underlying internal malignancy as he was a smoker. His chest X-ray revealed right sided hilar prominence with a mid zone cavity with fluid level. Fibreoptic bronchoscopy was done, there was one ulcerative growth in right middle lobe bronchus. Biopsy from the ulcer revealed probable squamous cell carcinoma. CT scan of thorax was also done and CT guided FNAC of Rt lung lesion yielded non small cell carcinoma. His skin lesions were also biopsied and diagnosis of acanthosis nigricans was confirmed. Here we report a case of acanthosis nigricans associated with non-small cell cancer of lung.

Acanthosis nigricans, tripe palms, and sign of Leser‐Trélat in a patient with gastric adenocarcinoma: case report and literature review in China

“…After clinical data analysis, stage IV gastric adenocarcinoma was diagnosed. MAN often regresses after suppression or removal of malignancy, 12 but unfortunately this patient strongly refused any palliative chemotherapy. It is necessary to exclude malignant diseases when the sudden presence of AN occurs in patients aged > 40 years, who have no previous endocrine disorder and genetic disease, especially with TP and LT sign; for these patients, it would be suggested to perform meticulous diagnostic investigation in order to exclude coexisting malignant disease.…”

A 68 year old male with abdominal pain, anorexia, and facial skin pigmentation

“…[ 1 ] It may be idiopathic. Secondary forms may be due to endocrinopathies[ 2 ] underlying cancer[ 1 3 ]; some drugs (Nicotinic acid, Stilbesterol, and Corticosteroids)[ 4 ] and familial forms. [ 5 ]…”

Keratinizasyon bozukluklarının paraneoplastik önemi

“…Sıklıkla akrokordonlar da eşlik eder 26 . En sık gastrointestinal 32 (%60 mide) yerleşimli adenokarsinom ve genitoüriner adenokarsinomlar 33 ile ilişki görülürken akciğer 34 , meme, pankreas, karaciğer, mesane, over, böbrek kanseri olmak üzere solid neoplaziler de akantozis nigrikansa yol açabilir 26 . Hastaların yaklaşık %60'ında deri lezyonları maliniteden önce ortaya çıkar 18 .…”