A case of Synchronous Malignancy of Stomach and Kidney

Abstract

The synchronous occurrence of primary renal cell carcinoma with gastric cancer is very rare. We report a case of 41 year old male who presented on 05/07/2011 to M S Ramaiah hospital, Bangalore with history of fever, pain abdomen and malena. Ultrasound abdomen and pelvis showed large heterogenous mass arising from the upper pole of left kidney. Computed tomography of the abdomen showed left renal cell carcinoma. Renal biopsy showed features consistent with renal cell carcinoma -clear cell type. Oesophagogastroduodenoscopy revealed gastric polypoidal growth. Gastric biopsy from the growth revealed poorly differentiated adenocarcinoma of stomach. We report this case to highlight a rare occurrence of synchronous malignancy of stomach and kidney.

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

“…The most commonly reported risk factor was smoking [2,4,17,18,20,[22][23][24][25]. The most frequent clinical presentations were upper or lower gastrointestinal (GI) bleeding, nonspecific Multiple combinations of surgical treatments are described, including partial gastrectomy/radical nephrectomy [5], subtotal gastrectomy/partial nephrectomy [6,19], total gastrectomy/radical nephrectomy [17,20], endoscopic gastric resection/radical nephrectomy [24], partial gastrectomy/total nephrectomy [17], mucosectomy/renal active surveillance [18], and total gastrectomy/renal active surveillance [22]. Among the surgical approaches for gastric cancer, partial gastrectomy was predominant, followed by total gastrectomy and subtotal gastrectomy.…”

“…With regard to the management of patients with renal carcinoma, multiple reviews revealed that radical nephrectomy was the most frequently performed surgical intervention, followed by total nephrectomy, partial nephrectomy, and two cases treated with active surveillance. Diagnostic renal carcinoma was more frequently on the left side with nephrectomy (partial, total, or radical) [5,6,19,[22][23][24].…”

“…Subsequently, the definition of a synchronous tumor was standardized, according to the time of diagnosis of the second primary malignancy (SPM), with the SPM diagnosed within a period of time no greater than 6 months after the diagnosis of the primary tumor. This definition is the one used for SPM identification in the literature review [2][3][4][5][6][7].…”

Synchronous malignancy of stomach and kidney: an unusual combination: a case report

“…12 Literature search shows only 3 cases reported from India. [13][14][15] Occurrence of multiple primary malignancies can be due to various genetic events or common environmental risk factors such as smoking, alcoholism, family history of cancer or immunological defects and prior irradiation or chemotherapy. 16 Various familial cancer syndromes are linked to SPM including lynch I and II syndromes, Li-Fraumeni syndrome, Fanconi anaemia, xeroderma pigmentosum and Von Hippel-Lindau.…”

“…2 Though the combination of gastro-intestinal and genitourinary tumours are not very uncommon, synchronous gastric and renal malignancies are very rare (0.11-0.37%) and only 3 cases have been reported from India. 3,[13][14][15]…”