A case of undetectable glycated hemoglobin (HbA1C)

Hegde, ShrikanthN; Srikousthubha, M S; Anupama, YJ; Rathnakar, Rathnakar

doi:10.1093/qjmed/hcy080

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Measuring Diabetes1

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2023

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Cited by 4 publications

(2 citation statements)

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“…On the other hand, Hegde et al [3] reported an undetectable HbA1c case, diagnosed as an HbD disease [3]. Nasir et al [4] compared the HbA1c values meas-This Case Report is accompanied by Editorial, see page 75. ured on HPLC and immunoassay in patients who were detected to have a hemoglobin variant after HbA1c analysis.…”

Section: Discussionmentioning

confidence: 99%

Undetectable Glycated Hemoglobin (HbA1c): An Interesting Case

Chung

Huang

2023

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Section: Discussionmentioning

confidence: 99%

Undetectable Glycated Hemoglobin (HbA1c): An Interesting Case

Chung

Huang

2023

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“…The processes responsible for type 1 and type 2 occur simultaneously i.e. they are comorbidities; thereby explaining to some extent the misdiagnoses when using the HbA1c test [21,22], but the test only measures the glycation process.…”

Section: Measuring Diabetesmentioning

confidence: 99%

A Discussion of the Current Limitations of Diabetes Etiology

2020

Endocrinol Diabetes Metab J

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The Biology of Diabetes The first step to consider in the process of Diabetes (DM) is that of genetic expression in which a wide spectrum of genes, currently considered to be more than 60 genes [1], coherently interact in order to express pre-pro-insulin (type 1 diabetes) however the interpretation of such data is complicated when considering that the spectrum of genes which express pre-pro-insulin can differ [2] e.g. between different racial subtypes. There are few instances, if any, where a single gene acts independently of all other genes in order to express a particular protein or where a single gene is considered to be responsible for a particular medical indication e.g. in the case of Rett's syndrome [3], which is considered to be widely attributable to a single mutation in the MECP2 gene, a more in-depth examination of the literature reveals a lack of certainty surrounding such a conclusion e.g. • 'Mutations in a gene called MECP2 underlie almost all cases of classic Rett syndrome' • 'Using a systematic gene screening approach, we have identified mutations in the gene (MECP2) encoding X-linked methyl-CpG-binding protein 2 (MeCP2) as the cause of some cases of RTT'. • 'In 5 of 21 sporadic patients, we found 3 de novo missense mutations in the region encoding the highly conserved

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Interference of hemoglobin variants in HbA1c quantification

Yadav

Mandal

2023

Clinica Chimica Acta

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A case of undetectable glycated hemoglobin (HbA1C)

Cited by 4 publications

References 3 publications

Undetectable Glycated Hemoglobin (HbA1c): An Interesting Case

Undetectable Glycated Hemoglobin (HbA1c): An Interesting Case

A Discussion of the Current Limitations of Diabetes Etiology

Interference of hemoglobin variants in HbA1c quantification

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