A Case Report: A Rare Case of Multiple Chest Wall Schwannomas Associated with Uterine Leiomyoma and Infertility

Abstract

Schwannomatosis is a tumor predisposition syndrome characterized by development of multiple schwannomas that are slow-growing encapsulating neurogenic tumors. It is a recurrent condition and patients lack usually the classic cutaneous stigmata, vestibular schwannomas or brain parenchyma tumors. Many papers have incriminated the mutation of the SMARCB1 gene in this disease which has been also observed in cases of uterine leiomyoma. This report describes a rare case of multiple chest wall schwannomas associated to a uterine fibroma. A genetic study done did not show any SMARCB1 gene mutation. Subsequently a further genetic counselling and a whole exome sequencing were recommended especially that the patient underwent many trials of failed IVF and two miscarriages despite resection of all the tumors.