A Case Report for Myopericarditis after BNT162b2 COVID-19 mRNA Vaccination in a Korean Young Male

Abstract

Mass vaccination with the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine (BNT162b2) in Korea has resulted in many reported adverse effects. These side effects are the object of much scrutiny in the medical community. We report the case of a 29-year-old male who was diagnosed with myopericarditis after his second dose of Pfizer-BioNTech COVID-19 vaccine. This patient is the second recognized case of Pfizer-BioNTech COVID-19 vaccine induced myopericarditis in Korea and the first to have recovered from it. He originally presented with chest discomfort and exertional chest pain. Lab tests revealed elevated cardiac marker levels and echocardiographic findings displayed minimal pericardial effusion, prompting diagnosis as myopericarditis. We decided on two weeks of outpatient treatment with non-steroidal anti-inflammatory drugs (NSAIDs) due to the patient's mild symptoms and his occupation in the military. When this proved insufficient, we shifted to combination therapy with low dose corticosteroids and NSAIDs. After two weeks of treatment, the patient's symptoms and pericardial effusion had improved, and he was recovered completely 37 days after the onset.

Myocarditis after COVID‐19 mRNA vaccination: A systematic review of case reports and case series

“…Further review identified a total of 57 studies reporting cases, case series, and summated case series of COVID‐19 vaccine‐associated myocarditis. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 59 , 60 , 61 , 62 , 63 , …”

“…We identified 201 studies relevant to COVID‐19 vaccination and myocarditis. Further review identified a total of 57 studies reporting cases, case series, and summated case series of COVID‐19 vaccine‐associated myocarditis 8–65 . A total of 275 cases of COVID‐19 vaccine‐associated myocarditis were reported.…”

Clinicopathological Characteristics of Inflammatory Myositis Induced by COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report

“…As more individuals were COVID-19 vaccinated, unexpected side effects appeared, making it challenging to prevent the COVID-19. 19 20 21 22 The most common systemic adverse effects were fever, fatigue, headache, and myalgia. Younger individuals reported more local or systemic adverse effects than older individuals.…”

A rare case of COVID-19 vaccine-induced myopericarditis in a young adult

“…Interestingly, the case being reported mutually showed elevated ANA titers, but unlike Badshah et al.’s case, it was negative for all other possible autoimmune disease antibody markers ruling out the potential impact of subclinical autoimmune predisposition on vaccine-induced myopericarditis in this case. In another recent case report from Korea, a 29-year-old male was diagnosed with myopericarditis after the second dose of the Pfizer-BioNTech COVID-19 vaccine [13] . According to Kim et al., this is “the second recognized case of Pfizer-BioNTech COVID-19 vaccine-induced myopericarditis in Korea and the first to have recovered from it” [13] .…”

“…In another recent case report from Korea, a 29-year-old male was diagnosed with myopericarditis after the second dose of the Pfizer-BioNTech COVID-19 vaccine [13] . According to Kim et al., this is “the second recognized case of Pfizer-BioNTech COVID-19 vaccine-induced myopericarditis in Korea and the first to have recovered from it” [13] . This case is similar to the case being reported in the sense that both patients revealed pericardial effusion with normal LVEF.…”