A Case Report: Long Post-COVID Vaccination Syndrome During the Eleven Months After the Third Moderna Dose

Abstract

It is undisputed that anti-SARS-CoV-2 vaccines can have side effects. Long post-COVID vaccination syndrome (LPCVS) is one of them and is often neglected. It persists 11 months after the third mRNA-1273 (Moderna) vaccine dose has not been reported. Our patient is a 39-year-old male with a largely uneventful previous history who developed severe adverse reactions immediately after the third dose of the mRNA-1273 (Moderna) vaccine. In addition to brief fever, headache, flickering eyes, skin rashes, tiredness, disorientation, dizziness (brain fog), tiredness, impaired thinking and concentration, and emotional disorders occurred as a result. Cerebral MRI showed non-specific white matter lesions in a frontotemporal distribution. Some of the immune parameters were deflected. Non-steroidal anti-inflammatory drugs, antihistamines, sartans, and statins have occasionally provided temporary relief. In conclusion, LPCVS is a definite complication of anti-SARS-CoV-2 vaccinations and can severely impact the quality of life and lead to disability. Despite extensive work-up, a clear cause for the long-term neuro-cognitive deficits cannot be identified. Symptomatic treatment can provide some relief. Patients with LPCVS should be taken seriously and treated appropriately.

COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): Similarities and differences

“…In January 2022 this topic was addressed in an article in Science concluding that the COVID-19 vaccines “may cause rare, Long Covid–like symptoms”. Different terms were used so far to refer to this conditions, including “Long post-COVID vaccination syndrome (LPCVS)” [305] , [306] , “post-vaccination individuals with PASC-like symptoms” [307] or “autoimmune post-COVID vaccine syndromes” [57] . In German speaking countries, the term “Post-Vakzin-Syndrom” or “Post-Vac-Syndrom” (translated into “post-vac syndrome”) is increasingly used in the media to refer to this condition.…”

Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization

“…This study is the largest 5 15 22–27 to describe people who report a severe, debilitating chronic condition following covid-19 vaccination. This chronic condition began soon after covid-19 vaccination and persisted in many people for a year or more.…”

“…14 A less well-characterized adverse event is a chronic syndrome with symptoms that begin soon after vaccination. 15 16 A recent preprint from the US National Institutes of Health described 23 people who reported neuropathic symptoms starting within 21 days after vaccination. 17 The cause of this syndrome is undefined, diagnostic tests and evidence-based interventions are lacking, and its connection with vaccination remains controversial.…”

COVID-19 vaccine adverse events: Evaluating the pathophysiology from an undersulfated and degraded glycocalyx perspective

“…Adding a sulfur donor, such as NAC, would ensure a better outcome during steroid treatment 21,98 . Patients taking moderate or high doses of corticosteroids, have an increased risk of COVID-19 and vaccine-induced complications 49,353 . In acute viral myocarditis, the use of NSAIDs remains controversial and has also shown increased myocardial inflammation and mortality in murine models and human case studies 205,350 .…”