A Case Report of a Patient with Charcot-Marie-Tooth Disease Complaining about Lower Limb Pain

문, 희영; 류, 광현; 추, 원정; 최, 요섭; 박, 지원; 김, 두리; 류, 원형; 전, 용현

doi:10.22246/jikm.2018.39.6.1321

Cited by 1 publication

(1 citation statement)

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“…For patients with a herniated intervertebral disc, herbal medicine treatment with Woongayoungsin-hwan has been proven effective in reducing low back pain, showing an improvement with a quick return to the activities of daily life activities and routine [ 27 ]. For patients with muscular atrophy in the lower limbs caused by a condition of peripheral neuropathy, Korean medicine treatment with Woongayoungsin-hwan has exhibited a significant therapeutic effect with a gradual increase in the duration of self-walking exercise time [ 28 ]. Disc pain and osteoarthritis have a similar etiopathogenesis, since proteoglycans, predominantly aggrecan, in the ECM of the nucleus pulposus and articular cartilage are lost in both cases [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

Park,

Choi,

Yeo

et al. 2024

PLoS ONE

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Osteoarthritis is the most prevalent type of degenerative arthritis. It is characterized by persistent pain, joint dysfunction, and physical disability. Pain relief and inflammation control are prioritised during osteoarthritis treatment Mume Fructus (Omae), a fumigated product of the Prunus mume fruit, is used as a traditional medicine in several Asian countries. However, its therapeutic mechanism of action and effects on osteoarthritis and articular chondrocytes remain unknown. In this study, we analyzed the anti-osteoarthritis and articular regenerative effects of Mume Fructus extract on rat chondrocytes. Mume Fructus treatment reduced the interleukin-1β-induced expression of matrix metalloproteinase 3, matrix metalloproteinase 13, and a disintegrin and metalloproteinase with thrombospondin type 1 motifs 5. Additionally, it enhanced collagen type II alpha 1 chain and aggrecan accumulation in rat chondrocytes. Furthermore, Mume Fructus treatment regulated the inflammatory cytokine levels, mitogen-activated protein kinase phosphorylation, and nuclear factor-kappa B activation. Overall, our results demonstrated that Mume Fructus inhibits osteoarthritis progression by inhibiting the nuclear factor-kappa B and mitogen-activated protein kinase pathways to reduce the levels of inflammatory cytokines and prevent cartilage degeneration. Therefore, Mume Fructus may be a potential therapeutic option for osteoarthritis.

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Section: Introductionmentioning

confidence: 99%