A case report of a xanthogranulomatous pyelonephritis case mimicking the recurrence of renal cell carcinoma after partial nephrectomy

AlDarrab, Rakan M; Alakrash, Hamad; Sultan, Alkhateeb; Albqami, Nasser

doi:10.4103/0974-7796.164857

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…XGP is a diagnostic dilemma preoperatively as the clinical and radiologic findings imitate both benign and malignant lesions. [2728] Histomorphology is pathognomonic with diffuse granulomatous inflammatory cell infiltrate. [8] There is an admixture of lipid-laden foamy macrophages, neutrophils, lymphocytes, plasma cells, and giant cells.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological spectrum of xanthogranulomatous pyelonephritis

Kundu¹,

Baliyan²,

Dhingra³

et al. 2019

Indian J Nephrol

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Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the clinicopathologic spectrum of XGP. Forty cases of XGP were diagnosed on histopathology over a period of 13 years (2005–2017). Relevant clinical details and radiological findings were recorded from the case files. Out of a total of 40 cases, 26 were female and 14 were male with a mean age of 39.5 ± 13.6 years. Flank pain was the most common presenting symptom. All the patients had unilateral disease and underwent nephrectomy for a nonfunctional kidney. Gross examination showed enlarged kidney with replacement of cortico-medullary tissue by yellow nodular areas of fatty tissue and dilatation of the pelvicalyceal system. Thirty-six (90%) cases had nephrolithiasis. Histologically, the characteristic feature was the existence of lipid-laden foamy macrophages. Renal parenchymal involvement was diffuse in majority (31, 77.5%). Two (5.0%) of the patients had coexisting carcinoma in the same kidney. Histopathologic examination gives the definitive diagnosis of XGP which relies on the characteristic morphology. Surgical intervention in the form of nephrectomy is the treatment of choice and offers good treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological spectrum of xanthogranulomatous pyelonephritis

Kundu¹,

Baliyan²,

Dhingra³

et al. 2019

Indian J Nephrol

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“…La incidencia de pielonefritis xantogranulomatosa es baja y se ha reportado que varía del 0.03% al 0.06% 1,2 . El estudio de esta patología está compuesto principalmente por reportes de casos, por lo que gran parte de la evolución natural de la enfermedad y el pronóstico de los pacientes se desconocen [1][2][3][4][5][6] .…”

Section: Introductionunclassified

Factores de riesgo preoperatorios en pacientes con pielonefritis xantogranulomatosa sometidos a nefrectomía

Avilés-Ibarra

Maldonado-Alcaraz

Carrasco-González

et al. 2021

CIRU

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“…The incidence of xanthogranulomatous pyelonephritis is low and has been reported to range from 0.03% to 0.06% 1,2 . The study of this pathology is mainly composed of case reports, which is why much of the natural evolution of the disease and patient prognosis are unknown [1][2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Preoperative risk factors in patients with xanthogranulomatous pyelonephritis undergoing nephrectomy

Avilés-Ibarra¹,

Maldonado-Alcaraz²,

Carrasco-González³

et al. 2023

CIRUE

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Objective: To identify preoperative risk factors associated with major complications in patients with xanthogranulomatous pyelonephritis undergoing total nephrectomy. Method: Retrospective analysis of patient's charts with xanthogranulomatous pyelonephritis who underwent nephrectomy. Risk factors included for analysis were gender, body mass index, Charlson comorbidity index, American Society of Anesthesiologists physical status classification, Malek's stage, leukocyte count and creatinine levels. Postoperative complications were stratified in minor and major according to Clavien-Dindo's classification. Univariate and bivariate analysis using Fisher's exact test, Pearson's chi-squared and odds ratio (OR) was performed. Results: 72 patients were analyzed, 83% women, mean age of 50 years, 58.3% positive urine cultures and 66% kidney stones. Major complications were present in 32% of cases, and 15% were admitted to the intensive care unit. Elevated creatinine (OR: 3.8; 95% confidence interval [95%CI]: 1.1-13; p = 0.02) and Malek's stage II to III (OR: 4.5;; p = 0.02) were associated with major complications. Conclusion: The Malek Stage and elevated creatinine increases the risk of major complications in patients undergoing nephrectomy due to xanthogranulomatous pyelonephritis.

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A case report of a xanthogranulomatous pyelonephritis case mimicking the recurrence of renal cell carcinoma after partial nephrectomy

Cited by 6 publications

References 7 publications

Clinicopathological spectrum of xanthogranulomatous pyelonephritis

Clinicopathological spectrum of xanthogranulomatous pyelonephritis

Factores de riesgo preoperatorios en pacientes con pielonefritis xantogranulomatosa sometidos a nefrectomía

Preoperative risk factors in patients with xanthogranulomatous pyelonephritis undergoing nephrectomy

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