A Case Report of Benign Schwannoma of the Liver

Özkan, Emine Elif; Güldür, Muhammet Emin; Uzunköy, Ali

doi:10.2169/internalmedicine.49.3486

Cited by 16 publications

(14 citation statements)

References 9 publications

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“…Since hepatic schwannoma is such a rare finding, a definitive diagnosis by radiological methods is difficult and they are sometimes misinterpreted as liver metastases or primary liver cancer. Surgery is typically required in order to establish the diagnosis and treatment (2).…”

Section: Introductionmentioning

confidence: 99%

Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

Wan

Zhai

Ren

et al. 2016

Molecular and Clinical Oncology

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Abstract. Hepatic schwannoma is a rare benign disease with a good prognosis. Early diagnosis is difficult due to the absence of specific clinical presentations and its rarity. The present study briefly described a 64-year-old female patient with hepatic schwannoma mimicking intrahepatic cholangiocarcinoma. Furthermore, the clinical data of 30 patients with hepatic schwannoma were also reviewed and analyzed. The mean age of the 30 patients was 51.7 years (range, 21-83 years) and ~2/3 were female. All patients in the benign group underwent surgical treatment and survived until the last follow-up, of whom 19 received complete resection and the remaining 1 underwent liver transplantation. However, in the malignant group, only three cases who underwent the surgical resection remained alive at last follow-up. Another seven cases were succumbed to mortality, 4 cases of whom had deteriorated to have no operation opportunity by the time they saw a doctor, and among the remaining three cases with hepatectomy, 1 died of liver dysfunction at 21 days postoperatively, 2 succumbed to recurrences at 18 and 23 months postoperatively. In conclusion, hepatic schwannoma is a rare benign disease with a good prognosis. However, once the malignant transformation occurs, the prognosis is not satisfied. Complete resection is the mainstay for cure and liver transplantation is often necessary.

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Section: Introductionmentioning

confidence: 99%

Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

Wan

Zhai

Ren

et al. 2016

Molecular and Clinical Oncology

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“…[10] In the abdominal cavity, schwannomas are most reported in the retroperitoneum [11] and gastrointestinal tract. [12,13] The occurrence of schwannomas in the porta hepatis, [7] gallbladder, [8] pancreas, [14] or liver [15] is extremely rare. To our knowledge, only 18, 15, and 6 cases of schwannomas involving the liver, [5,6] porta hepatis, and gallbladder, [8] respectively, have been reported.…”

Section: Discussionmentioning

confidence: 99%

Multiple schwannomas synchronously occurring in the porta hepatis, liver, and gallbladder

Guo

Shen

et al. 2016

Medicine

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Background:Schwannomas are mesenchymal neoplasms that arise from Schwann cells with low malignant potential. Schwannomas originating from the porta hepatis or intra-abdominal organs are extremely rare. To our knowledge, multiple schwannomas synchronously occurring in the porta hepatis, liver, and gallbladder have not been reported so far and we first report one in the present case.Case summary:A 31-year-old female was referred to our hospital because of repeated abdomen discomfort, slight abdominal distension, and occasional abdominal pain for seven years. Ultrasound and computed tomography and magnetic resonance cholangiopancreatography found multiple intrahepatic and extrahepatic cystic lesions with the dilation of intrahepatic and extrahepatic bile ducts. By exploratory laparotomy, multiple tumors were found in the porta hepatis, liver, and gallbladder, the biggest one was 11 × 6 cm in size. We completely resected these tumors combined with the left lateral liver lobe, gallbladder, and the invaded left and right hepatic arteries, and then severed vessels were reconstructed. Microscopically, the tumor cells were spindle shaped and palisading arrangement. Atypical cells or signs of malignancy were not found. Immunohistochemical investigation showed the protein S-100 was positive, while SMA, CD34, and CD117 negative. Finally, these tumors were diagnosed as schwannomas in the porta hepatis, liver, and gallbladder. The patient is followed-up for 70 months and has been doing well without any complications.Conclusion:We report the first patient with multiple schwannomas synchronously occurring in the porta hepatis, liver, and gallbladder. Accurate preoperative diagnosis of these tumors is difficult. Due to closely adhering to the surrounding important tissues, complete removal is challenging.

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“…Although a schwannoma may arise from any organ that contains peripheral nerves, primary hepatic schwannomas are extremely rare. According to English medical literature, only 19 cases of hepatic schwannoma, including the presently reported case, have been documented (Table 1) [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]. These 19 cases consisted of 9 men (47.1%) and 10 women (52.9%), with a median age of 56 years (range, 21–83 years).…”

Section: Discussionmentioning

confidence: 99%