A case report of brain abscess caused by Nocardia farcinica

Song, Jiangqin; Lian, Dong; Ding, Yan; Zhou, Junyang

doi:10.1186/s40001-021-00562-2

Cited by 10 publications

(16 citation statements)

References 25 publications

(31 reference statements)

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“…There are only 9 strains that are isolated from eyes among 441 different Nocardia strains collected by Wang et al [ 1 ] N. farcinica usually causes mild keratitis through exogenous routes (e.g., lens abrasion) or causes more severe endophthalmitis, invades the brain, lungs or other tissues, leading to purulent lesions through endogenous routes (e.g., hematogenous dissemination). [ 11 , 12 ] Once the infection occurs, the onset of disease is acute, but the development is rapid with strong invasiveness, severe tissue destruction and long course of treatment. [ 13 ] The patient in this study is a decoration worker.…”

Section: Discussionmentioning

confidence: 99%

Successful control of scleritis caused by Nocardia farcinica: A case report

et al. 2022

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Rationale: Nocardia farcinica is an opportunistic pathogen that rarely causes ocular infections. This study reviewed a case of N. farcinica-mediated scleritis involving the corneal limbus. Patient concerns: A 56-year-old man was admitted to the Department of Keratology of Jinan Second People’s Hospital due to “a red and swollen right eye accompanied with severe pain for >1 month.” He denied any history of hypertension, diabetes, systemic immune diseases and eye surgery. Diagnoses: Corneal defect and scleral necrosis were observed by slit lamp. Combination of anterior segment optical coherence tomography and ophthalmic ultrasound biomicroscopy was used for diagnosis and evaluation of corneal and scleral conditions. Culture and metagenomic sequencing verified that the pathogen of scleritis was N. farcinica. Interventions: The patient was treated by sulfacetamide sodium eye drops, oral administration of sulfamethoxazole tablets, amikacin anterior chamber flushing, scleral debridement, and allogeneic scleral transplantation. Outcomes: The disease was successfully controlled. Lessons: Infectious scleritis caused by N. farcinica is extremely rare. Culture of pathogenic microorganisms remains to be the gold standard for the diagnosis of infectious eye diseases. Metagenomic sequencing shows potential promise in the diagnosis of infectious eye diseases. N. farcinica is sensitive to sulfonamides and amikacin.

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Section: Discussionmentioning

confidence: 99%

Successful control of scleritis caused by Nocardia farcinica: A case report

et al. 2022

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“…Literature is limited to case reports and few case series published, although incidence seems to be growing [3]. Sixteen different species of Nocardia are known to cause clinical manifestations in humans, with the most commonly reported species in the literature being N. asteroides, N. farcinica, and N. cyriacigeorgica [1,4].…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral nocardiosis is rare and usually manifests as brain abscesses, although cerebral infiltration, meningitis, ventriculitis, and spinal cord infections have been reported [3]. Nocardial brain abscess accounts for 2% of all cerebral abscesses carrying the highest mortality rate among bacterial abscesses [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Nocardia Brain Abscess in a Patient With Sarcoidosis

Ghazal¹,

Botchway²,

Naut³

2022

Cureus

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Nocardia species are aerobic, gram-positive, filamentous bacteria. Infection occurs either through inhalation leading to pulmonary symptoms or inoculation presenting with skin findings. Hematogenous dissemination, although uncommon, is possible and can lead to central nervous system involvement. Nocardia brain abscess is a rare manifestation that comprises 2% of all brain abscess etiologies, mostly occurring in immunocompromised patients. Establishing a diagnosis is often difficult, especially due to its rare occurrence and the fact that it can mimic other etiologies on brain imaging including necrotic tumors. High mortality rates have been reported due to delays in establishing a diagnosis and a lack of precise treatment guidelines.

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“…Our case is consistent with this pattern, that is multiple cavities occurring and changing over a short period of time. The next is the nervous system, common imaging findings include brain abscess, granulomatous formation or diffuse infiltration [ 16 , 17 ], meningitis, epidural and paraspinal abscesses [ 18 , 19 ]. This case has no typical brain MRI performance.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Nocardia farcinica involves the spinal cord: a case report and review of the literature

Zhang

et al. 2021

BMC Infect Dis

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Background Nocardia is a relatively rare opportunistic pathogenic bacteria group, commonly seen in patients with immunocompromised or defective immune system. It can affect multiple organs of the body and cause disseminated infection, among which most occurs in the lung, secondly in the nervous system, soft tissues, rare in the spinal cord and pituitary. No case has been reported involving lung, spinal cord, skin and pituitary gland at the same time. Case presentation We report a 55-year-old female with Nocardia infection involving the lung, skin, spinal cord, and pituitary gland. The patient underwent a full set of imaging examinations and showed typical imaging findings. Chest computed tomography (CT) showed multiple nodules with cavities in the lungs. The magnetic resonance imaging (MRI) of the vertebral body showed abnormal signal of the entire spinal cord with cavity formation and ring enhancement. The subcutaneous nodules of the abdomen were punctured under ultrasound. Through the etiological tissue culture of subcutaneous nodules and the second generation sequencing of cerebrospinal fluid, the diagnosis was finally confirmed. Conclusion Disseminated Nocardiosis is an uncommon disease. This article will report a rare case of disseminated Nocardiosis simultaneously involving the lung, spinal cord, subcutaneous soft tissue and pituitary gland, especially with neuropathy as the initial symptom. Imaging is helpful for the early diagnosis of the disease and pathological and microbiological examinations are helpful for its confirming.

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A case report of brain abscess caused by Nocardia farcinica

Cited by 10 publications

References 25 publications

Successful control of scleritis caused by Nocardia farcinica: A case report

Successful control of scleritis caused by Nocardia farcinica: A case report

Nocardia Brain Abscess in a Patient With Sarcoidosis

Disseminated Nocardia farcinica involves the spinal cord: a case report and review of the literature

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