A case report of combination of asthma and allergic rhinitis caused by local household sensitization with a brief analysis of literature

Abstract

Currently diagnosis of allergic diseases is based largely on results of skin tests and laboratory methods of quantification of total and specific immunoglobulins E in serum in addition to clinical and instrumental data. However, in recent years it has been showed that systemic atopy is not always registered with these methods and specific immunoglobulins E may not have diagnostic concentrations in serum that makes it difficult to diagnose allergic diseases. The article presents a clinical case of combination of asthma and allergic rhinitis caused by local IgE production with normal level of serum I-4, reduced levels of IgG1, IgG2 and serum and secretory IgA in child aged 3 years.