A case report of giant retroperitoneal hemolymphangioma.

Kanaitsuka, Toshihiro; Itani, Kenji; Shigeta, Hirofumi; Yamamura, Yoshiharu; Kogawa, Takafumi; Yoshikawa, Toshikazu; Saito, Shigeru; Kanatsuna, Takahiro; Kondou, M.; TAKASHINA, Kenichirou; MAEDA, Takemasa; Ashihara, Tsukasa

doi:10.2169/naika.76.1595

Cited by 12 publications

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“…Within AP-1, c-Fos heterodimerizes via leucine zipper (LZ)/leucine zipper interactions with various partners (Chinenov and Kerppola, 2001), the best known being the Jun family members, and binds to specific DNA motifs (AP-1/TRE and CRE) via a basic domain (DBD) N-terminally adjacent to the LZ (Piechaczyk and Blanchard, 1994;Chinenov and Kerppola, 2001). c-fos gene is expressed constitutively in a variety of embryonic and adult tissues (see Curran, 1988;Piechaczyk and Blanchard, 1994;Herdegen and Waetzig, 2001) as well as in a number of tumor cells that, nonexhaustively, include certain osteosarcomas (Gamberi et al, 1998), HTLV-I-infected T cells (Fujii et al, 1991), smouldering adult T leukemia cells (Iwahashi et al, 1994), B-cell lymphomas (Kanaitsuka et al, 1987(Kanaitsuka et al, , 1988, Philadelphia chromosome positive chronic myelogenous leukemia (Eibl et al, 1995), glioma cells (Rubio et al, 1996;Kim et al, 2000), bovine leukemia virus (BLV)-infected cells (Tajima and Aida, 2002), theileria-transformed bovine leucocytes (Chaussepied et al, 1998). In most other cell types, where its expression is low or undetectable, c-fos gene is induced by a wide array of stimuli to permit cell to integrate changes in the extracellular environment (see Curran, 1988;Piechaczyk and Blanchard, 1994;Herdegen and Waetzig, 2001).…”

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confidence: 99%

The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression

et al. 2003

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c-fos gene is expressed constitutively in a number of tissues as well as in certain tumor cells and is inducible, in general rapidly and transiently, in virtually all other cell types by a variety of stimuli. Its protein product, c-Fos, is a short-lived transcription factor that heterodimerizes with various protein partners within the AP-1 transcription complex via leucine zipper/leucine zipper interactions for binding to specific DNA sequences. It is mostly, if not exclusively, degraded by the proteasome. To localize the determinant(s) responsible for its instability, we have conducted a genetic analysis in which the half-lives of cFos mutants and chimeras made with the stable EGFP reporter protein were compared under two experimental conditions taken as example of continous and inducible expression. Those were constitutive expression in asynchronously growing Balb/C 3T3 mouse embryo fibroblasts and transient induction in the same cells undergoing the G0/G1 phase transition upon stimulation by serum. Our work shows that c-Fos is degraded faster in synchronousthan in asynchronous cells. This difference in turnover is primarily accounted for by several mechanisms. First, in asynchronous cells, a unique C-terminal destabilizer is active whereas, in serum-stimulated cells two destabilizers located at both extremities of the protein are functional. Second, heterodimerization and/or binding to DNA accelerates protein degradation only during the G0/G1 phase transition. Adding another level of complexity to turnover control, phosphorylation at serines 362 and 374, which are c-Fos phosphorylation sites largely modified during the G0/G1 phase transition, stabilizes c-Fos much more efficiently in asynchronous than in serum-stimulated cells. In both cases, the reduced degradation rate is due to inhibition of the activity of the C-terminal destabilizer. However, in serum-stimulated cells, this effect is partially masked by the activation of the N-terminal destabilizer and basic domain/leucine zipper-dependent mechanisms. Taken together, our data show that multiple degradation mechanisms, differing according to the conditions of expression, may operate on c-Fos to ensure a proper level and/or timing of expression. Moreover, they also indicate that the half-life of c-Fos during the G0/G1 phase transition is determined by a delicate balance between opposing stabilizing and destabilizing mechanisms operating at the same time.

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confidence: 99%

The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression

et al. 2003

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“…There have been only 2 cases reported on PubMed, 1 was a giant celiac hemolymphangioma, 12 the other is a multiple celiac hemolymphangioma. 14 And characteristics were shown in Table 1 .…”

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confidence: 99%

Multiple Hemolymphangioma of the Visceral Organs

Zhang

Wang

et al. 2015

Medicine

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Hemolymphangioma is a rare disease with malformation of both lymphatic and vascular vessels. Few cases of hemolymphangioma occurring in the rectum, small intestine, pancreas, esophagus, and other organs have been reported. Nevertheless, multiple hemolymphangioma of the visceral organs are extremely rare. We report a 25-year-old female with a significantly enlarged spleen full of multiple-rounded lesions. Curiously, the splenic flexure and even retroperitoneum had many lesions. The patient recovered well after splenectomy and the pathologic diagnosis of spleen was hemolymphangioma with abnormal lymphatic and blood vessels with polycystic spaces.Usually, it is hard to cure this disease. We should take much more consideration into the diagnosis, treatment, and even pathogenesis, even though it is a benign lesion.

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“…Hemolymphangioma has been previously detected at the pancreas (5,7-12), spleen (13)(14)(15)(16), stomach (1,17), rectum (18), mediastinum (19)(20)(21), chest wall (22)(23)(24)(25), small intestine (26), extremities (3,27,28), cervix (29,30), pericardium (31), oral region (32), esophagus (33), axilla (34), retroperitoneal space (35,36), adrenal gland (37), abdomen (38), duodenum (4) and hepatica (39), as well as on the tongue (40,41) and orbit (42,43). However, to the best of our knowledge, no studies have reported this type of tumor in the waist region, as determined by a review of the medical literature until June 2014 using the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed; accessed on 9th June 2014).…”

Section: Introductionmentioning

confidence: 99%

Hemolymphangioma of the waist: A case report and review of the literature

Pang

Yang

et al. 2015

Oncology Letters

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Abstract. Hemolymphangioma is a malformation of the lymphatic and blood vessels. To the best of our knowledge, only a limited number of hemolymphangioma cases have been reported in the literature thus far, with no cases developed in the waist region. The present study reported the case of a 17-year-old male patient with hemolymphangioma growing on the waist, presented with back pain for four months. Upon physical examination, the lesion was identified to be oval in shape, soft and compressible, with mild tenderness. No abnormalities were detected in the results of laboratory examinations. However, a magnetic resonance imaging (MRI) scan revealed a tumor with low signal intensity on T1-weighted imaging (WI) and high signal intensity on T2-WI. The mass was successfully removed during surgery. During the seven-month follow-up period, the patient was asymptomatic with no evidence of recurrence. The present study discussed the imaging findings and pathological features of this uncommon case and reviewed the relevant literature. IntroductionLymphangioma, also known as angioma lymphaticum, is a congenital malformation of the vascular system, comprising newly-formed lymph spaces and channels (1). Landing and Farber (2) classified this benign malformation in four categories, including capillary, cavernous and cystic (hygroma) lymphangioma, and hemolymphangioma, which is a combination of hemangioma and lymphangioma.Hemolymphangioma is a congenital malformation that may be asymptomatic for a long period of time (3). This lesion is typically considered to be a benign and noninvasive disorder, characterized by the presence of dilated lymphatic spaces, extravasation of red blood cells, hemosiderin deposition and fibrosis (4). Hemolymphangioma formation may be due to venolymphatic communication obstruction between the dysembrioplastic vascular tissue and systemic circulation (5).The incidence of hemolymphangioma is 1.2-2.8 per 1,000 newborn infants (6). Hemolymphangioma has been previously detected at the pancreas (5,7-12), spleen (13-16), stomach (1,17), rectum (18), mediastinum (19-21), chest wall (22-25), small intestine (26), extremities (3,27,28), cervix (29,30), pericardium (31), oral region (32), esophagus (33), axilla (34), retroperitoneal space (35,36), adrenal gland (37), abdomen (38), duodenum (4) and hepatica (39), as well as on the tongue (40,41) and orbit (42,43). However, to the best of our knowledge, no studies have reported this type of tumor in the waist region, as determined by a review of the medical literature until June 2014 using the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed; accessed on 9th June 2014). Complete excision is considered the optimal treatment for hemolymphangioma, which exhibits a low recurrence rate. Non-surgical treatments are also used, including aspiration and drainage, cryotherapy, injection of sclerotic agents, laser therapy and radiotherapy, however, to date, the outcomes of such treatments have been unsatisfactory (3,22). In cases of tumor recurrence, conservative treatmen...

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A case report of giant retroperitoneal hemolymphangioma.

Cited by 12 publications

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The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression

The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression

Multiple Hemolymphangioma of the Visceral Organs

Hemolymphangioma of the waist: A case report and review of the literature

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