Osteomyelitis is a severe condition characterized by the infection and inflammation of the bone and its bone marrow, thus quickly impacting the Harversian systems. It is often caused by bacteria, the methicillin-resistant S. aureus bacteria being the most common organism. Conventional treatment typically involves long-term antibiotic therapy, surgical debridement, and supportive measures. However, the increasing prevalence of antibiotic resistance and the adverse effects emphasize the need for complementary and alternative treatment approaches. The rationale for Ayurvedic is that inflammatory swelling is correlated with vidradhi. This case report discusses about the chronic inflammation of osteomyelitis caused by fracture of the humerus with mal-union which has been treated successfully through an Ayurvedic approach by administering Varunaadi Gana Kashaya (decoction), Nyagrodhadi Gana Kashaya (decoction), Arogyavardhini Vati (tablet), Lakshadi Guggulu (tablets), Local application of Jatyadi Taila (oil). Results: The patient was followed up every 7 days while on ayurvedic treatment. In the initial days, the wound was closed with a cast; after 10 days, the cast was removed, and discharge was drastically reduced culminating in overall wound healing. Conclusion: This case report highlights the successful management of osteomyelitis using Ayurvedic medicine as an adjunct therapy. The individualized Ayurvedic treatment plan, including internal medicine, external applications, and lifestyle modifications, contributed to symptom improvement, reduced inflammation, and promoted healing in the patient.