A Case Report of Primary Hepatic Squamous Cell Carcinoma That Remarkably Responded to Low Dose Arterial Injection of Anti-Cancer Drugs

Kaji, Ryohei; Sasaki, Natsuki; Tateishi, Ikuo; Nagata, Eisuke; Okabe, Yoshinobu; Yoshida, Takafumi; Sata, Michio; Ueno, Takato

doi:10.2739/kurumemedj.50.71

Cited by 22 publications

(23 citation statements)

References 9 publications

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“…This observation was incompatible with typical CE-US findings of cholangiocarcinoma, metastatic adenocarcinoma, or hepatocellular carcinoma [11]. Meanwhile, CT and MRI images of the present tumor were almost compatible with those in previous hepatic SCC cases [7, 10, 12]. Immunohistochemical analysis (anti-CD31 or anti-CD34) revealed abundance of capillary endothelial vessels in this tumor.…”

Section: Discussioncontrasting

confidence: 76%

Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Iimuro¹,

Asano²,

Suzumura³

et al. 2011

Case Rep Gastroenterol

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Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US) demonstrated unique enhancement in the late vascular phase, which was incompatible with those observed in hepatocellular carcinoma, cholangiocellular carcinoma, or metastatic adenocarcinoma. The patient underwent surgical resection of the tumor followed by systemic chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP), while radiation chemotherapy was not applied because of relatively poor performance status. Although postoperative image analysis revealed no recurrence 4 months later, the patient died 13 months after the operation from recurrence. Immunohistological analysis of the resected specimen revealed that this SCC contained many capillary endothelial vessels expressing CD31 or CD34, possibly reflecting the unique imaging pattern in the late vascular phase of CE-US, which has been reported in choangiolocellular carcinoma. In addition, we reviewed which kind of treatment would be suitable for advanced hepatic primary SCC in the literature. From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver.

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Section: Discussioncontrasting

confidence: 76%

Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Iimuro¹,

Asano²,

Suzumura³

et al. 2011

Case Rep Gastroenterol

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“…Hepatectomy, systemic chemotherapy (5-fluorouracil and cisplatin), or TACE could be considered for the treatment [55,56].…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

Tan

Xiao

2012

Abdom Imaging

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“…Eine weitere Typisierung hinsichtlich des Ausgangsortes ist am histologischen Bild und auch immunhistologisch für diesen Tumortyp nicht möglich. Als seltene Differenzialdiagnose finden sich das squamoide CCa und einzelne in der Literatur berichtete Fälle von primären Plattenepithelkarzinomen der Leber [20,21,24,25].…”

Section: Differenzialdiagnose Von Lebermetastasen Nach Dem Histologisunclassified

Lebermetastasen: Inzidenz und histogenetische Einordnung

et al. 2005

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Metastases are the most common malignant tumors of the liver. In the files of the Institute of Pathology of the University of Cologne 12,161 liver tissue cases are registered. Of them, 1,357 cases (11.2%) showed tumors or tumor like masses. Liver metastases of solid tumors were the largest group of the neoplasias with 611 cases (5.0%) followed by hepatocellular carcinoma (380 cases; 3.1%). Other entities were rare and include cholangiolar carcinoma (0.5%), vascular tumors (0.4%), lymphomas (0.4%), focal nodular hyperplasias (0.36%) and liver cell adenomas (0.23%). Adenocarcinomaa are the largest group of metastases with 400 cases (65.5%). 48.2% of this group were metastases of colorectal cancer, 13.5% of pancreatic cancer, 13% of breast cancer, 6.2% of gastric cancer, 4.5% of lung cancer and 3.7% of esophageal cancer. Neuroendocrine carcinomas are the second largest group with 16% of liver filiae. Other entities were rarely found. Metastases in cirrhotic livers are seldom. The gross findings, the histology, the differential diagnosis including immunohistochemistry and the value of the liver biopsy is discussed.

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A Case Report of Primary Hepatic Squamous Cell Carcinoma That Remarkably Responded to Low Dose Arterial Injection of Anti-Cancer Drugs

Cited by 22 publications

References 9 publications

Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Rare hepatic malignant tumors: dynamic CT, MRI, and clinicopathologic features: with analysis of 54 cases and review of the literature

Lebermetastasen: Inzidenz und histogenetische Einordnung

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