A Case Report of Risperidone-Induced Obsessive-Compulsive Symptoms

al-Zaid, K; Jones, Barry D.

doi:10.1097/00004714-199702000-00014

Cited by 32 publications

(4 citation statements)

References 2 publications

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“…A small open-label trial of risperidone monotherapy in childhood tic disorders demonstrated significant reduction in tics in 7 of 7 patients, and in obsessive compulsive symptoms in 1 of 3 children with comorbid OCD (Lombroso et al 1995). However, it should be noted that there are also reports of risperidone-induced tics and OCD (Alzaid and Jones 1997;Dodt et al 1997;Dryden-Edwars and Reiss, 1996;Edelman 1997).…”

mentioning

confidence: 99%

Risperidone Augmentation of Serotonin Reuptake Inhibitor Treatment of Pediatric Obsessive Compulsive Disorder

Fitzgerald¹,

Stewart²,

Tawile³

et al. 1999

Journal of Child and Adolescent Psychopharmacology

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In this case series, risperidone augmentation of treatment with a serotonin reuptake inhibitor (SRI) is described in four pediatric patients diagnosed with obsessive compulsive disorder (OCD). An improved treatment response was observed in all cases, albeit in different ways. All four of the patients had failed prior SRI monotherapy. Comorbid tics were observed in two cases and aggressive behavior or violent images were seen in three. Possible predictors of response to risperidone in patients with OCD and future research avenues are explored.

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confidence: 99%

Risperidone Augmentation of Serotonin Reuptake Inhibitor Treatment of Pediatric Obsessive Compulsive Disorder

Fitzgerald¹,

Stewart²,

Tawile³

et al. 1999

Journal of Child and Adolescent Psychopharmacology

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“…A differential response to risperidone was described in an adolescent boy who had an elimination of psychotic symptoms but an incapacitating exacerbation of OC symptoms (Dryden-Edwards and Reiss 1996). Risperidone has been noted also to induce OC symptoms in adults (Alzaid and Jones 1997;Mahendran 1998).…”

Section: Discussionmentioning

confidence: 99%

Separation Anxiety in Children and Adolescents Treated with Risperidone

Hanna¹,

Fluent²,

Fischer³

1999

Journal of Child and Adolescent Psychopharmacology

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Risperidone is an atypical antipsychotic that has been investigated as a treatment for several severe psychiatric disorders in children and adults. A low dose of risperidone was added to other medications to treat two adolescent boys with obsessive compulsive disorder (OCD) and a childhood history of separation anxiety disorder, and one prepubertal boy with a history of attention deficit hyperactivity disorder and escalating behavior suggestive of mania. Each patient developed severe separation anxiety that resolved when risperidone was discontinued. The response was similar to that described in Tourette's disorder patients treated with haloperidol and pimozide. Two of the patients were treated subsequently with olazapine without a recurrence of separation anxiety. We discuss the diagnostic issues concerning separation anxiety induced by antipsychotic medications, and suggest that the atypical antipsychotics may differ in their tendency to elicit separation anxiety.

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“…Dryden-Edwards and Reiss 24 Alzaid and Jones 25 Chong et al 26 Alevizos et al 27 pathologies might imply dynamic dysfunctions anywhere along these two distinct corticostriatalthalamocortical neural networks with non-orthogonal behaviors. For instance, among schizophrenia patients, 5-HT and dopamine are likely in equilibrium in the orbitofrontal cortex.…”

Section: Mahedran 2 'mentioning

confidence: 99%

The Paradox of Quetiapine in Obsessive-Compulsive Disorder

Tranulis¹,

Potvin²,

Gourgue³

et al. 2005

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Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.

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A Case Report of Risperidone-Induced Obsessive-Compulsive Symptoms

Cited by 32 publications

References 2 publications

Risperidone Augmentation of Serotonin Reuptake Inhibitor Treatment of Pediatric Obsessive Compulsive Disorder

Risperidone Augmentation of Serotonin Reuptake Inhibitor Treatment of Pediatric Obsessive Compulsive Disorder

Separation Anxiety in Children and Adolescents Treated with Risperidone

The Paradox of Quetiapine in Obsessive-Compulsive Disorder

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