A Case Report of Severe Malaria Associated Acute Renal Failure in an Adult

Abstract

Malaria continues to be a significant global public health problem, particularly in endemic nations. A 28-year-old male was brought into the emergency room with significant complaints of fatigue, chills, fever, and lack of appetite. The patient had no prior history of malaria. He was not given any anti-malarial medication as prophylaxis while traveling to his workplace. As a result of laboratory investigations to identify malarial parasites in peripheral blood using thin and thick smears, malaria parasites were found in the patient. Cardiovascular testing confirmed that S1 and S2 were audible. At the border of the colitis, the liver was palpable. Both the chest X-ray and abdominal ultrasonography were clear. His level of consciousness assessment indicated a Glasgow coma scale reading of 10 out of 15. As part of her supportive care, he received 1000 mL of normal saline solution with 40% glucose solution. He received intravenous artesunate 60 mg (2.4 mg/kg) when he was admitted to the intensive care unit, and then every twelve and twenty-four hours for the following three days (a total of three doses, 540 mg).

Prophylaxis Failure and Successful Management of Delayed-Onset Malaria with Renal Complications: A Case Report with Oral Artemether-Lumefantrine Treatment

“…Supportive therapy in our case is in line with WHO recommendations as well as experiences presented in various studies [2, 17,18,[21][22][23][24][25][26]. The study provides valuable insights into the clinical features and management of severe malaria cases, emphasizing the importance of intensive care unit management [14,20].…”

“…Five dialysis sessions were applied to the patient, which indicates the serious involvement of the kidneys, a recognized complication of severe malaria [18][19][20]. The importance of supportive treatment and dialysis in the treatment of cases of severe malaria with AKI has been proven once again in our case, described widely in different papers dealing with severe malaria with AKI [19][20][21][22][23][24][25][26][27]. The improvement of the patient's condition is closely related to the immediate administration of antimalarial therapy (even oral) and the timely initiation of dialysis.…”