A Case Report on Methotrexate Overdose Induced Pancytopenia and Mucocutaneous Ulcerations

Srinivasa, Brunda Mysore; Padmini, S; Kumar, Praveen; Philip, Aneena Annu; Presannan, Athira K; Thomas, R.; Arif, Arshiya

doi:10.5530/ijopp.13.4.61

Cited by 3 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…El 11% puede tener afectación del sistema nervioso central, manifestada por cefalea, confusión, somnolencia e incluso convulsiones sin evidencia radiológica de lesiones. La toxicidad hematológica puede presentarse en un 3% de los pacientes, con su efecto máximo entre el 4.° y 13.° día, llegando a la recuperación entre los días 14 y 21 días, con altas tasas de mortalidad de hasta el 80% 9,[12][13][14] . En nuestro caso evidenciamos efectos de toxicidad hematológica dados por anemia, leucocitopenia, neutropenia profunda y plaquetopenia, desde el segundo día y sin llegar a recuperar los valores basales.…”

Section: Discussionunclassified

Falla orgánica secundaria a intoxicación por metotrexato, ¿la diálisis es una alternativa? Reporte de caso

Llerena-Rengel,

Basantes-Borja,

Alvear-Matailo

2024

GAMO

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Section: Discussionunclassified

Falla orgánica secundaria a intoxicación por metotrexato, ¿la diálisis es una alternativa? Reporte de caso

Llerena-Rengel,

Basantes-Borja,

Alvear-Matailo

2024

GAMO

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“…The severe acute toxicity is rare and mostly presents with cutaneous ulceration, bone marrow suppression and mucositis [4,5,6]. Approximately 78% of MTX treated psoriasis patient develop adverse drug reactions (ADR) where nausea and vomiting are common adverse reaction with ecchymosis, reversible alopecia, pruritus and in severe cases include acute ulcerations of psoriatic plaques, toxic epidermal necrolysis and mucosal erosions [7]. Most cases occurs as a result of the inadvertent overdosing due to erroneously taking drugs daily [4].…”

Section: Introductionmentioning

confidence: 99%

Methotrexate Induced Oral Mucositis and Bone Marrow Suppression in Psoriatic Patient

Aadithya,

Prabhu,

2024

Int. J. Med. Pharm. Case Rep.

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Methotrexate is an antimetabolite which binds to the dihydrofolate reductase enzyme and used in the treatment of malignant disorders and autoimmune diseases. Myelosuppression is a serious complication of methotrexate toxicity. The following case describes a case of 67 year old male patient diagnosed with psoriasis and wrongly taken methotrexate 7.5 mg daily for 3 days and twice daily for 4 days. He presented with oral mucositis and his lab reports showed myelosuppression. Our case emphasizes the significance of effective patient counselling to ensure the understanding of prescription and to prevent drug toxicity. The key learning points of our case report include the importance of adhering to prescribed medication regimens, awareness of MTX toxicity, early initiation of folinic acid as an antidote, vigilant monitoring of toxicity, and effective patient education on proper medication use. Adherence to established MTX therapy guidelines in dermatological conditions is crucial to minimize the risk of patient.

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Methotrexate-induced Severe Pancytopenia in a Patient with Rheumatoid Arthritis: A Case Report and Review of Literature

Shahbazi

Hosseini

2024

CDS

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Toxicity associated with low doses of methotrexate (MTX) is low, but it may be fatal. Bone marrow suppression and mucositis are among the common side effects of low dose MTX toxicity. Different risk factors have been reported for toxicities associated with low doses of MTX, including accidental use of higher doses, renal dysfunction, hypoalbuminemia, and polypharmacy. In this paper, we present a female patient who had mistakenly used 7.5 mg of MTX daily instead of the same dose of MTX on Thursday and Friday. She was presented with mucositis and diarrhea to the emergency department. Moreover, we searched the databases Scopus and PubMed for available studies and case reports on toxicities associated with MTX dosing errors. The most frequently observed toxicities included gastrointestinal lesions, nausea, vomiting, skin lesions, and bone marrow suppression. Leucovorin, hydration, and urine alkalinization were among the most frequently used treatments. Finally, we summarize the data on the toxicities of low doses of MTX in different diseases.

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A Case Report on Methotrexate Overdose Induced Pancytopenia and Mucocutaneous Ulcerations

Cited by 3 publications

References 6 publications

Falla orgánica secundaria a intoxicación por metotrexato, ¿la diálisis es una alternativa? Reporte de caso

Falla orgánica secundaria a intoxicación por metotrexato, ¿la diálisis es una alternativa? Reporte de caso

Methotrexate Induced Oral Mucositis and Bone Marrow Suppression in Psoriatic Patient

Methotrexate-induced Severe Pancytopenia in a Patient with Rheumatoid Arthritis: A Case Report and Review of Literature

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