A case series of hematohidrosis: A puzzling medical phenomenon

Shahgholi, E

doi:10.24953/turkjped.2018.06.022

Cited by 13 publications

(20 citation statements)

References 9 publications

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“…The pathophysiology of hematohidrosis remains unclear. Several hypotheses have been proposed including abnormal constriction and then dilation of capillary vessels to the point of rupture, dermal vasculitis, and stromal weakness due to defects in the dermis [4,6]. From our investigation, we could postulate that the basic pathogenesis of hematohidrosis might be perplexing regulation disturbance of central nervous system-hypothalamus-autonomic nervous system pathway in association with histaminergic activation.…”

Section: Discussionmentioning

confidence: 64%

“…The diagnosis of hematidrosis could be made by recurrent, spontaneous and self-limited bleeding which is witnessed by medical personnel, and by identifying all blood components in the bleeding samples leaking from intact skin and mucous membrane without any lesion observed [4]. Hematidrosis affects more females than males, usually with an onset in adolescence [1,3].…”

Section: Discussionmentioning

confidence: 99%

“…After that a few additional cases were also described. There was generally only one case described in each report, except for a series of three children [4], and other four patients discovered by separated ENT specialists from South Africa [5].…”

Section: Introductionmentioning

confidence: 99%

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Hematidrosis: Pathophysiology and Therapeutic Strategy

Wang¹,

Yin²,

Yu³

et al. 2021

Preprint

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Background: Hematidrosis is an extremely rare and mysterious disorder. The etiology and pathophysiology of this disorder remain mostly unknown, and there is no specific therapeutic strategy available up to now.Methods: The clinical features, hemostatic and other laboratory tests, and bloody exudates of seven patients were investigated, and histologic examination of the affected skin was performed. They were treated with a new therapeutic regimen. Results: The bleeding episodes could appear under different conditions, but often following physical or emotional stress, with some prodromes. The frequency and amount of bleeding varied with each individual. The effluent bloody samples showed all the components of the peripheral blood, mingled with a few epithelial cells. Histologic examination of the affected skin showed normal sweat glands containing no blood. Each of patients was treated individually, and a multi-drug "cocktail therapy" regimen mainly consisting of beta-receptor blocker, anxiolytic, and histamine H1/H2 receptor antagonists proved successful. Although most patients could relapse within 6 to 12 months, the treatment was still effective and they were finally cured. Conclusion: nervous system-hypothalamus-autonomic nervous system pathway in association with histaminergic activation. A multi-drug "cocktail therapy" in accordance to this hypothesis would become a new effective regimen.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Hematidrosis: Pathophysiology and Therapeutic Strategy

Wang¹,

Yin²,

Yu³

et al. 2021

Preprint

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“…The exclusion of all known diseases that can be considered as possible differentials led to the diagnosis of a haematidrosis-like disease in this dog. Although the strict diagnostic criteria for human haematidrosis have not been defined, the diagnosis of this phenomenon is typically based on a compatible history of episodic, spontaneous cutaneous bleeding, the occurrence of at least one episode under direct medical supervision (in order to exclude nonreported self-trauma), the microscopic confirmation of the bloody nature of the fluid and the exclusion of bleeding disorders [1][2][3]5,[19][20][21]. The dog of this report fulfilled all the above diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

“…Haematidrosis in humans is a rare phenomenon, with multiple causes and triggering factors and with an ill-defined pathogenesis that is clinically characterised by episodic, nontraumatic, bloody sweating [1][2][3][4][5]. To the best of our knowledge, a similar phenomenon in animals has not yet been described, with the only exception some anecdotal reports of haematidrosis in horses with infectious anaemia, purpura haemorrhagica and other bleeding disorders [6] and well-documented cases of bovine neonatal pancytopenia [7].…”

Section: Introductionmentioning

confidence: 99%

Excitement-Induced Cutaneous Bleeding (Haematidrosis-like) in a Dog

Sofou

Gavra

Saridomichelakis

2021

Veterinary Sciences

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A 15-month-old intact female Pitbull was referred because of recurrent, episodic, self-limiting, excitement-induced bleeding from nontraumatised skin. No abnormalities were detected upon physical examination. Subsequently, the dog went for a walk under the direct supervision of one of the authors, became overexcited and, after approximately five minutes, bloody liquid, with a patchy distribution, appeared along the hair shafts of the face and neck. The affected skin was congested, partially blanching on diascopy and bloody liquid was oozing from the follicular openings. Urticaria, dermographism and hypertension were excluded, the complete blood count and coagulation profile were within the reference ranges and an analysis of the bloody exudate confirmed its blood components. The cutaneous bleeding of the dog followed a self-limited course, with no episodes during the last two years. Clinical and laboratory findings and the long-term evolution of this dog bear striking similarities to haematidrosis, a rare human disease of multifactorial aetiology and equivocal pathogenesis.

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Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Goh,

Wee,

Chua

et al. 2023

Semin Thromb Hemost

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Hematohidrosis, or hematidrosis, is a rare medical condition characterized by blood oozing from the intact skin in the absence of a bleeding problem. 1 Prior to modern-day medical literature, these phenomena had been captured in Renaissance and also present-day artwork. While the purpose of medical literature is to aid healthcare professionals and patients in the better understanding and treatment of disease, a significant proportion of Renaissance art commissioned by the church depicted scenes from the Bible, for the purposes of a visual depiction of key events to promote teachings of the faith, and to encourage devotion to God.We explored the theme of hematohidrosis in historic art and performed a rapid review of modern medical literature, noting that the earliest works featuring hematohidrosis were depictions in Renaissance art as early as the 15th century. The German painter known as Meister Der Freisinger Passion (Master of the Freising Passion) depicts Jesus Christ in the Garden of Gethsemane at the foot of the Mount of Olives, sweating drops of blood (►Fig. 1). Around him, his disciples sit, fast asleep. Another piece given the same name, the Christus am Ölberg, is featured in one of the frescoes of the Tabernakelbildstock in Welsberg-Taisten (Wayside Shrine of Tesido; ►Fig. 2). Believed to have been painted by Wolfgang Sauber in the 1460s, it depicts Christ with his hands clasped together in prayer as bloody sweat dots his forehead. These two artworks provide visual testimony to Luke's account of the Gospel of Jesus Christ praying in the Garden of Gethsemane before crucifixion. The motif of the cup is featured in the two artworks, echoing Christ's words in Luke 22:42, "Father, if you are willing, remove this cup from me. Nevertheless, not My will, but Yours, be done." The cup is a symbol of the cup of God's wrath that Jesus takes upon Himself, as He takes on the sins of the nations. In the words of preacher Charles Spurgeon, "at one tremendous draught of love, He drank damnaarticle published online

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A case series of hematohidrosis: A puzzling medical phenomenon

Cited by 13 publications

References 9 publications

Hematidrosis: Pathophysiology and Therapeutic Strategy

Hematidrosis: Pathophysiology and Therapeutic Strategy

Excitement-Induced Cutaneous Bleeding (Haematidrosis-like) in a Dog

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

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