Anoxic–oxic process is also called anaerobic aerobic process and used widely with the membrane bioreactor (MBR) for wastewater treatment, particularly in China, thanks for their high efficiency, good-quality permeate and easy operation. However, because the content of the feed wastewater fluctuates in a large range and the operation condition of the system needs to be controlled accurately, it is very important to find an efficient way to constantly monitor the nodes of the system, and adjust the operation parameters, including the quantities used in the chemical treatment. Therefore, it is necessary to use Internet of things technology (IOT) sensing and control equipment to realize the dynamic monitoring of sewage treatment process parameters, so as to serve the drug delivery and equipment online control. This study introduces an application case based on IOT sensor control and supporting maintenance business. Through the practical application of this technology in an environmental protection sewage treatment enterprise in Wuxi, this study introduces a method of bringing the IOT into the MBR system of industrial wastewater treatment which can continuously and accurately monitoring the nodes of the system. Based on this study, an analysis and decision-making system based on real-time monitoring data can be realized to adjust operation parameters in time. In this method, the IOT is introduced into the MBR system of industrial wastewater treatment. The results show that with the support of IOT, the sewage treatment system runs stably and the treatment efficiency is significantly improved.