A Case with Juvenile Xanthogranuloma and Progressive Nodular Histiocytosis Overlap

Guidolin, Lucia; Noguera‐Morel, Lucero; Hernández‐Martín, Ángela; Fernández‐Llaca, Héctor; Rodríguez‐Peralto, José Luis; Torrelo, Antonio

doi:10.1111/pde.13073

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…PNH belongs to a subgroup of unifying non-Langerhans cell histiocytoses (NLCHs), or the xanthogranuloma (XG) family (2). It displays a progressive clinical course with no signs of spontaneous resolution, and is characterized by the histological finding of a nodular infiltrate of spindle cells in a storiform arrangement intermingled with foamy cells and Touton giant cells (3,4).…”

mentioning

confidence: 99%

Progressive Nodular Histiocytosis with Large Nodules and a Bulky Mass

Kiyohara

Makimura²,

Miyamoto³

et al. 2019

Acta Derm Venerol

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confidence: 99%

Progressive Nodular Histiocytosis with Large Nodules and a Bulky Mass

Kiyohara

Makimura²,

Miyamoto³

et al. 2019

Acta Derm Venerol

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“…Lesions with overlapping features have been described. Entities with JXG and PNH overlap are on record [9,35], as are lesions with clinicopathologic features that bridge PNH and multiple AXG [12]. There have also been well-documented cases of transformation of one entity into another, e.g., BCH evolving to JXG [36] and GEH morphing into XD, JXG, or PNH [37].…”

Section: Discussionmentioning

confidence: 99%

Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature

Numbere

Pukhalskaya

Bowman

et al. 2021

Case Reports in Pathology

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Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehead and right temple. These lesions were initially diagnosed as xanthomas and did not respond to intralesional injections of triamcinolone. Additional biopsy revealed an intense dermal infiltrate of foamy mononuclear epithelioid cells with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. On immunohistochemical staining, the lesional cells were positive for CD163 and CD68 and negative for CD1a, thus confirming a mononuclear-macrophage lineage. The clinical presentation and the histological impression lead to the diagnosis of PNH. This condition could be challenging, mimicking microscopically similar lesions of the non-Langerhans cell histiocytosis group. Although uncommon, PNH stands out due to its clinical and microscopic features and should be taken into consideration in the differential diagnosis of cutaneous histiocytoses.

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“…Corticosteroid treatment as intralesional injection, pulse therapy, and continuous daily treatment (10-70mg/day oral prednisone) has been reported [5][6][7]. Electrodesiccation and curettage of disfiguring lesions has been reported in a pediatric patient with satisfactory cosmetic results [2]. Systemic chemotherapeutic agents like vincristine, cyclophosphamide, and prednisolone have been tried without success [4,13].…”

Section: Case Discussionmentioning

confidence: 99%

“…Progressive nodular histiocytosis (PNH) is an infrequent form of non-Langerhans cell histiocytosis (LCH) of the xanthogranuloma group, which includes juvenile xanthogranuloma, xanthoma disseminatum, benign cephalic histiocytosis, multiple adult xanthogranuloma, and generalized eruptive histiocytosis. It was first described in 1978 by Taunton [1][2][3]. Currently, fewer than 20 cases can be found on a PubMed search of reports indexed for MEDLINE.…”

Section: Introductionmentioning

confidence: 99%