A Case with Membranous Glomerulonephritis and Myelodysplastic Syndrome

Paydas, S; Tuncer, İlhan; Zorludemir, Suzan; Gönlüşen, Gülfiliz

doi:10.1159/000187040

Cited by 13 publications

(23 citation statements)

References 3 publications

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“…A variety of glomerulonephritides have been reported to be associated with myelodysplastic syndrome (Figure 3), and in general, their response to immunosuppressive treatment is good 74–76. Only one case of membranous nephropathy and one of membranoproliferative glomerulonephritis have been reported in association with CMML; possibly because kidney biopsy is frequently contraindicated in these patients 77.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

“…Data are taken from several sources54–56,59–61,64–72,74–77,79,102–114 and are presented as numbers of specific types of paraneoplastic glomerulonephritis associated with different myeloid malignancies. Abbreviations: AML, acute myeloid leukemia; CML, chronic myelogenous leukemia; CMML, chronic myelomonocytic leukemia; ET, essential thrombocythemia; FibGN: fibrillary glomerulonephritis; FSGS, focal segmental glomerulosclerosis; IgAN: IgA nephropathy; MDS, myelodysplastic syndrome; MesPGN: mesangial proliferative glomerulonephritis; MCD, minimal change disease; MN, membranous nephropathy; MPGN: membranoproliferative glomerulonephritis; PMF, primary myelofibrosis; PV, polycythemia vera; RPGN, rapidly progressive glomerulonephritis.…”

Section: Figures and Tablesmentioning

confidence: 99%

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Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

2010

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Paraneoplastic glomerulonephritis is a rare complication of malignancy that is frequently mistaken for idiopathic glomerulonephritis. Failure to recognize paraneoplastic glomerulonephritis can subject patients to ineffective and potentially harmful therapy. Pathology of paraneoplastic glomerulonephritis varies between different types of malignancies. This Review describes the association of glomerulonephritis with both solid tumors and hematological malignancies The pathogenetic mechanisms of many glomerular lesions seem to relate to altered immune responses in the presence of a malignancy Studies in the Buffalo/Mna rat model of spontaneous thymoma and nephrotic syndrome indicate that polarization of the immune response toward a T-helper-2 (T H 2) profile has an important role in the development of thymoma-associated glomerular lesions. Furthermore, overexpression of the T H 2 cytokine interleukin 13 in transgenic rats induces minimal change disease. Such findings from experimental studies might facilitate the identification of biomarkers that can distinguish paraneoplastic glomerulonephritis from idiopathic and other secondary glomerulonephritides. This Review describes potential pathogenetic mechanisms for paraneoplastic glomerulonephritides associated with different malignancies and highlights the need for a multidisciplinary approach to the management of patients with paraneoplastic glomerulonephritis.

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Section: Hematological Malignanciesmentioning

confidence: 99%

Section: Figures and Tablesmentioning

confidence: 99%

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

2010

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“…A Medline search for the period 1986-2000 yielded only 16 cases of adult MDS patients with glomerulopathies, described in case reports [11,13] or in small series [6,12,14]. Clinically significant glomerular disease was found in 4/825 [12], in 2/221 [6], and in 5/125 [14] de novo MDS patients.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically significant glomerular disease was found in 4/825 [12], in 2/221 [6], and in 5/125 [14] de novo MDS patients. Clinical manifestations included nephrotic syndrome, usually accompanied by renal insufficiency [6,11,12,14], and acute or chronic or rapidly progressive glomerulonephritis [6,12]. Renal biopsy, when performed, disclosed membranous nephropathy in two patients [6,11], crescentic (extracapillary) glomerulonephritis in two [12,13], mesangial proliferative glomerulonephritis, diffuse (but not specified further) in one [14] or focal and segmental with mesangial IgA, IgG, and C3 deposition in one [6], and AL amyloidosis in one patient [12].…”

Section: Discussionmentioning

confidence: 99%

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Glomerular involvement in myelodysplastic syndromes

Bogdanović¹,

Kuzmanović²,

Marković-Lipkovski³

et al. 2001

Pediatric Nephrology

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Several reports have documented various forms of glomerular diseases in adults with myelodysplastic syndromes (MDS), but similar reports in children are lacking. We describe two children with MDS-associated steroid-responsive nephrotic syndrome (NS). Patient 1, who had MDS with myelofibrosis, presented with hepatosplenomegaly, pancytopenia, chronic hepatitis, moderate proteinuria, hypocomplementemia and elevated ANA titer. During initial prednisone treatment proteinuria markedly diminished and partial but transient hematological improvement occurred. Relapse subsequently occurred that manifested by overt NS and pancytopenia. High doses of prednisolone led to remission of the renal disease, but hematological remission did not occur. Persisting pancytopenia and repeated infections terminated in sepsis, 2 years after the onset of the MDS. Patient 2, who had refractory anemia with clonal monosomy 19, presented with bowel disease, hepatosplenomegaly, anemia and non-organ-specific autoantibodies. Prednisone led to both clinical and hematological remission. The hematologic disease relapsed 12 months later, when nephrotic-range proteinuria, hematuria and mild azotemia were also found. Corticosteroid treatment led to long-lasting renal and hematologic remission, maintained by a small dosage of prednisone. In both patients, renal biopsy findings were consistent with those seen in idiopathic NS. A Medline search disclosed 16 cases of glomerulopathy in the course of MDS in adult patients. Clinical features included NS, usually accompanied by renal insufficiency with acute, chronic, or rapidly progressive glomerulonephritis. On biopsy, membranous nephropathy, crescentic or mesangial proliferative glomerulonephritis, and AL amyloidosis were found. We conclude: (1) that glomerular disease may be present and should be searched for in patients with MDS and (2) that MDS can be added to the list of rare conditions associated with corticosteroid-responsive NS in children.

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The burden of autoimmunity in myelodysplastic syndromes

Fozza

2017

Hematological Oncology

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The clinical history of patients with myelodysplastic syndromes (MDS) is characterised by bone marrow insufficiency as well as by the possible evolution into acute leukaemia. However a number of reports highlight the frequent occurrence of autoimmune manifestations involving different sites and organs. The present review will first describe the clinical pictures most often observed in MDS patients. The actual burden of autoimmunity will be then addressed by focusing on the few available registry studies. Finally, the potential collateral impact of specific treatments for MDS on the evolution of autoimmune disorders will be considered.

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A Case with Membranous Glomerulonephritis and Myelodysplastic Syndrome

Cited by 13 publications

References 3 publications

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis

Glomerular involvement in myelodysplastic syndromes

The burden of autoimmunity in myelodysplastic syndromes

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