A catalytic approach to the base-promoted reaction of epoxides with activated methylenes

Definition of green synthetic tools based on safer reaction media, heterogeneous catalysis, and flow technology

“…In addition, flow chemistry represents a unique opportunity for innovating synthetic strategies and if properly applied, may be a powerful tool to minimize the waste associated to the chemical production of complex molecules [69][70][71].…”

“…We have used flow technology as an effective mixing technology in the combination of heterogeneous catalysts (organic and organometallic) and green reaction media such as azeotropes, water and also solventfree conditions proving that with this approach the chemical efficiency as well as the greenness of a synthetic methodology can be effectively maximized and some examples will be described below [66,[69][70][71][72][73][74][75][76][77][78].…”

Diastereoselective Three‐Step Route to o‐(6‐Nitrocyclohex‐3‐en‐1‐yl)phenol and Tetrahydro‐6H‐benzo[c]chromen‐6‐ol Derivatives from Salicylaldehydes

“…[3,10] Recently, we have thoroughly investigated the synthesis of a variety of chromene-based compounds, [11] which are a class of valuable heterocycles endowed with potent biological activity as toxins [12] that have been employed in medicine [13] and material science. [14] Our interest in this class of compounds stems from their chemical versatility because their functionalized skeleton can be used to synthesize complex molecular structures.…”

“…[1] Our research group has been committed to the development of efficient synthetic protocols that mainly use either water as reaction medium [2] or solvent-free conditions (SolFC). [3] In particular, we have paid attention to the preparation of valuable heterocyclic moieties such as 1H-triazoles and 1H-tetrazoles, [4] dihydrodibenzo [b,d]furans, [5] biphenyl-2-carbonitrile derivatives, [6] benzo[e]1,4-oxathiepin-5-ones, [7] quinoxaliniuim, and thiazolopyridinium salts.…”

2‐tert‐Butylimino‐2‐diethylamino‐1,3‐dimethylperhydro‐1,3,2‐ diazaphosphorine Supported on Polystyrene (PS‐BEMP) as an Efficient Recoverable and Reusable Catalyst for the Phenolysis of Epoxides under Solvent‐Free Conditions

“…We have been paying much attention to the reactivity of epoxides and we have developed several protocols for both their preparation and ring-opening by carbo-and heteroatomic nucleophiles such as azido ion, halides, amines and thiols, proving that the use of alternative reaction media such as water [11] or SolFC [12] is crucial for improving the efficiency of these processes. In our previous works we had not applied our strategy to the definition of a protocol for the reaction of epoxides with phenols.…”