A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses

Staunton, Donald E.; Merluzzi, Vincent J.; Rothlein, Robert; Barton, Randall W.; Marlin, Steven D.; Springer, Timothy A.

doi:10.1016/0092-8674(89)90689-2

Cited by 788 publications

(468 citation statements)

References 26 publications

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“…Interestingly, ICAM-I has been shown to serve as the ligand for rhinoviruses and some strains of coxsackie virus, as well as for leukocytes (66,67). The sites within the molecule bound by these viruses overlap with, but differ from, those portions of ICAM-I responsible for adhesion to leukocytes (65)(66)(67)(68). Monoclonal anti-ICAM-I antibodies are now being studied for their utility as antiinflammatory and antirheumatic agents.…”

Section: Immunoglobulin Superfamily Adhesive Moleculesmentioning

confidence: 99%

The adhesion molecules of inflammation

Cronstein

Weissmann

1993

Arthritis & Rheumatism

246

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Section: Immunoglobulin Superfamily Adhesive Moleculesmentioning

confidence: 99%

The adhesion molecules of inflammation

Cronstein

Weissmann

1993

Arthritis & Rheumatism

246

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“…ICAM-1 has been shown to be an important receptor for the majority of human rhinoviruses, an interaction that initiates entry of the virus into the host cell. 15,[37][38][39] Mutational and antigenic analyses localized the rhinovirus binding site to domain Ig-1 of ICAM-1 and demonstrated that Ig-3, Ig-4 and Ig-5 domains are also important for the accessibility of the rhinovirus binding site. 36,40 Therefore, a combination of allele K469 and R241 in domain Ig-5 and Ig-3, respectively, of ICAM-1 molecule may influence susceptibility to viral infection, an often suspected environmental factor in MS pathophysiology.…”

mentioning

confidence: 99%

Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis

et al. 2003

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Intercellular adhesion molecule-1 (ICAM-1) and its receptors are adhesion molecules that play a key role in the transmigration of inflammatory cells through the blood-brain barrier, one of the earliest events in multiple sclerosis (MS), which leads to demyelination in the central nervous system. To investigate the role of genes encoding ICAM-1 and its receptors, we used a strategy of genetic linkage and association in 439 case-parent MS families of French origin, well characterized according to HLA status and severity. We demonstrate that the genes encoding ICAM-1 receptors do not influence MS susceptibility or severity. ICAM-1 had a modest, but significant effect on MS genetic susceptibility, independent of HLA and disease severity. We observed a rare, and an as yet unreported, ICAM-1 gene haplotype defined by amino acids K469 and R241 that was never transmitted to patients suggesting a protective effect against MS in our population.

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“…In antigen presenting cells including macrophages, ICAM-1 participates in cell-cell interactions during antigen presentation while in other cell types ICAM-1 functions in microbial pathogenesis and as a signal transduction molecule. 25,26 Physiologically, ICAM-1 is expressed at a low basal level, 27 however during inflammatory and immune responses, ICAM-1 level increased substantially and aberrantly at sites of inflammation contributing to a number of inflammation-related diseases and injuries such as endotoxin-induced airway disease 28,29 and asthma, 27,30 arthritis, 31 ulcerative colitis 32 and chronic cholangiopathies. 21 In cancer, ICAM-1 has been mainly implicated in local inflammatory tumor microenvironment, 33 tumor progression and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

et al. 2016

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Circular RNAs (circRNAs) constitute a large class of RNA species formed by the back-splicing of co-linear exons, often within protein-coding transcripts. Despite much progress in the field, it remains elusive whether the majority of circRNAs are merely aberrant splicing by-products with unknown functions, or their production is spatially and temporally regulated to carry out specific biological functions. To date, the majority of circRNAs have been cataloged in resting cells. Here, we identify an LPS-inducible circRNA: mcircRasGEF1B, which is predominantly localized in cytoplasm, shows cell-type specific expression, and has a human homolog with similar properties, hcircRasGEF1B. We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs. These findings expand the inventory of functionally characterized circRNAs with a novel RNA species that may play a critical role in fine-tuning immune responses and protecting cells against microbial infection.

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A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses

Cited by 788 publications

References 26 publications

The adhesion molecules of inflammation

The adhesion molecules of inflammation

Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

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