A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments

Yang, Xiaorong; Nao, Sang-Cuo; Lin, Chuankai; Kong, Lingtan; Wang, Jing; Ko, Chung-Nga; Liu, Jinbiao; Ma, Dik‐Lung; Leung, Chung‐Hang; Wang, Wanhe

doi:10.1016/j.ejmech.2023.115659

Cited by 7 publications

(4 citation statements)

References 76 publications

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“…979 Liu, Leung, Wang, and co-workers have designed an iridium(III) complex conjugated with a PSMA inhibitor (526) (Chart 241) for imaging PSMA in prostate cancer microenvironments. 980 The complex displays high binding affinity for PSMA (K d = 9.49 nM), which is over 1,000-fold stronger than a Glu−urea-based PSMA inhibitor (K d = 12.4 μM). The complex has been used to visualize LNCaP cells in both 2D and 3D cultures, resulting in intense emission on the plasma membrane of the cells.…”

Section: Proteinsmentioning

confidence: 99%

“…Liu, Leung, Wang, and co-workers have designed an iridium(III) complex conjugated with a PSMA inhibitor ( 526 ) (Chart ) for imaging PSMA in prostate cancer microenvironments . The complex displays high binding affinity for PSMA ( K d = 9.49 nM), which is over 1,000-fold stronger than a Glu–urea-based PSMA inhibitor ( K d = 12.4 μM).…”

Section: Luminescent Transition Metal Complexes As Probes For Biologi...mentioning

confidence: 99%

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Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

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Section: Proteinsmentioning

confidence: 99%

Section: Luminescent Transition Metal Complexes As Probes For Biologi...mentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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“…Chen et al reported that PSMA-targeted NIRF dyes for PSMA FGS and DyLight800-10 achieved the highest uptake in PCa tumors 96 (Table 5 ). Furthermore, Yang et al conjugated an iridium(III) complex with the inhibitor Lys-urea-Glu to create a PSMA-targeted iridium(III) probe 97 .…”

Section: Psma-fgsmentioning

confidence: 99%

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Jiao,

Zhang,

Wen

et al. 2024

Theranostics

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Radical prostatectomy (RP) combined with pelvic lymph node dissection (PLND) is the first step in multimodal treatment of prostate cancer (PCa) without distant metastases. For a long time, the surgical resection range has been highly dependent on the surgeon's visualization and experience with preoperative imaging. With the rapid development of prostate-specific membrane antigen positron emission tomography and single-photon emission computed tomography (PSMA-PET and PSMA-SPECT), PSMA-targeted surgery has been introduced for a more accurate pathological diagnosis and complete resection of positive surgical margins (PSMs) and micro-lymph node metastases (LNMs). We reviewed PSMA-targeted surgeries, including PSMA-PET-guided prostatic biopsy (PSMA-TB), PSMA-targeted radio-guided surgery (PSMA-RGS), PSMA-targeted fluorescence-guided surgery (PSMA-FGS), and multi-modality/multi-targeted PSMA-targeted surgery. We also discuss the strengths and challenges of PSMA-targeted surgery, and propose that PSMA-targeted surgery could be a great addition to existing surgery protocols, thereby improving the accuracy and convenience of surgery for primary and recurrent PCa in the near future.

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“…6). 106 Lys-urea-Glu, a PMSA inhibitor, was conjugated into iridium( iii ) complex. 107,108 The bioconjugate 26 exhibited maximum excitation at 330 nm and a broad emission band with a maximum peak at around 670 nm in CH 3 CN.…”

Section: Targetable Imaging Applications Of Iridium(iii)–peptide Bioc...mentioning

confidence: 99%

Luminescent iridium(iii)–peptide bioconjugates for bioanalytical and biomedical applications

Jing,

Wu,

Chan

et al. 2024

Inorg. Chem. Front.

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A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments

Cited by 7 publications

References 76 publications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Luminescent iridium(iii)–peptide bioconjugates for bioanalytical and biomedical applications

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