A Cell Line Defective in Murine Coronavirus Internalization

Abstract

Murine coronavirus (MHV) infections of continuous cell lines show a wide spectrum of cell-virus interactions. Cell lines have been identified that can be lytically infected, persistently infected, or non-infectable (1,2,3). At present the mechanisms involved in determining the outcome of the infectious process are not clearly understood. In previous work a cell line, the rat C6 glial line, was identified that was resistant to infection by both the ~1HV3 and JHM strai ns of MHV (l). Studi es have been i niti ated to exami ne the reasons for this restriction in order to understand mechanisms whereby cells can be refractory to coronavirus infections and to understand the replication strategy of these agents.