A century of exercise physiology: key concepts in muscle cell volume regulation

Lindinger, Michael I.

doi:10.1007/s00421-021-04863-6

Cited by 6 publications

(4 citation statements)

References 119 publications

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“…In the first study, after three, 3 min cycling bouts at 120% V O 2max , the m. vastus lateralis total water content and extracellular (interstitial) water content both increased, whilst the intracellular water content was unchanged (313 vs. 359, 34 vs. 60 and 280 vs. 299 ml·100 g dry weight −1 , rest vs. exercise, respectively (Sjøgaard and Saltin 1982 ). These increases in muscle water with intense exercise are due to increased intracellular and extracellular osmolality, with the intracellular changes mainly due to increases in creatine, inorganic phosphate and lactate resulting from metabolic activity (Lindinger 2022 ). The decline in [K + ] i was from 161 to 141 mM after exercise, whilst [Na + ] i was unchanged (Sjøgaard 1983 ).…”

Section: Na + and K + Ion Conce...mentioning

confidence: 99%

“…In general, earlier studies measured K + c in blood via flame photometry or later by atomic absorption spectrophotometry, whilst many later studies utilised automated K + -selective electrodes, with most reporting [K + ] in plasma. K + regulation and exercise has been the focus of numerous excellent reviews that focus on implications for human integrative physiology, including muscle fatigue, heart function, blood flow and ventilation, as well as examining the roles of other tissues such as red cells and of fluid shifts per se (McKenna 1992 ; Lindinger and Cairns 2021 ; Sejersted and Sjøgaard 2000 ; Hostrup et al 2021 ; Lindinger et al 1995 ; Lindinger 2022 ; Renaud et al 2023 ).…”

Section: Plasma [K + ] During and Following Exerci...mentioning

confidence: 99%

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A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments

McKenna,

Renaud,

Ørtenblad

et al. 2024

Eur J Appl Physiol

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This historical review traces key discoveries regarding K+ and Na+ ions in skeletal muscle at rest and with exercise, including contents and concentrations, Na+,K+-ATPase (NKA) and exercise effects on plasma [K+] in humans. Following initial measures in 1896 of muscle contents in various species, including humans, electrical stimulation of animal muscle showed K+ loss and gains in Na+, Cl− and H20, then subsequently bidirectional muscle K+ and Na+ fluxes. After NKA discovery in 1957, methods were developed to quantify muscle NKA activity via rates of ATP hydrolysis, Na+/K+ radioisotope fluxes, [3H]-ouabain binding and phosphatase activity. Since then, it became clear that NKA plays a central role in Na+/K+ homeostasis and that NKA content and activity are regulated by muscle contractions and numerous hormones. During intense exercise in humans, muscle intracellular [K+] falls by 21 mM (range − 13 to − 39 mM), interstitial [K+] increases to 12–13 mM, and plasma [K+] rises to 6–8 mM, whilst post-exercise plasma [K+] falls rapidly, reflecting increased muscle NKA activity. Contractions were shown to increase NKA activity in proportion to activation frequency in animal intact muscle preparations. In human muscle, [3H]-ouabain-binding content fully quantifies NKA content, whilst the method mainly detects α2 isoforms in rats. Acute or chronic exercise affects human muscle K+, NKA content, activity, isoforms and phospholemman (FXYD1). Numerous hormones, pharmacological and dietary interventions, altered acid–base or redox states, exercise training and physical inactivity modulate plasma [K+] during exercise. Finally, historical research approaches largely excluded female participants and typically used very small sample sizes.

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Section: Na + and K + Ion Conce...mentioning

confidence: 99%

Section: Plasma [K + ] During and Following Exerci...mentioning

confidence: 99%

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments

McKenna,

Renaud,

Ørtenblad

et al. 2024

Eur J Appl Physiol

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“…In modern medicine in the 18th century, the word "Medicina Gymnastica: or a treatise concerning the power of exercise, concerning the economy: and the great necessity of it in the cure of several distempers" was published in 1705 by the London physician, Francis Fuller. In 1927, the Harvard Fatigue Laboratory was established and after several decades of research, the field of Exercise Physiology began researching the importance of exercise for sports performance, physical and mental training, health, and injury recovery, and various recovery therapies have been widely recognized [44]. [25].…”

Section: History Of Collective Exercisementioning

confidence: 99%

An Overview of the Relationship Between Dietary Behavior and Lifestyle to Health at Molecular Biology Mechanism

Lê

Nguyen

NGUYEN

2023

Tạp chí Dinh dưỡng và Thực phẩm

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Following the green revolutions, the industrial revolution, and the fourth industrial wave, the quantity of food, goods, and products that serve human life has reached unprecedented levels. Advancements in agriculture productivity, production, and processing technologies, as well as smart supply chain control, have contributed to the "surplus crisis" of food in most countries, including Vietnam. The majority of the world's population consumes diets with excessive levels of fat, sugar, salt, and a lack of fiber. These unhealthy eating habits are known to be the main causes of chronic diseases, acting as silent killers of the health and lifespan of contemporary human society. Fortunately, a new trend of nutritious diets rich in fiber, positive thinking habits, exercise, and a harmonious lifestyle has been discovered as a "reform pill" for humans. This article presents a synthesis and update of relevant research achievements, with the ambition to positively adjust unscientific eating habits and change negative thinking and behavior to improve the health and lifespan of human society.

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“…in Greece was the first to provide a written exercise prescription, and Galen (129–210 A.D.) recommended to include regular physical activity in the management of avoiding illness ( Tipton, 2014 ). While physiological concepts at that time were far from current understanding, it were findings from seminal research work published in the first three decades of the 20th century that laid the foundations of modern exercise physiology ( Lindinger, 2022 ). For instance, August Krogh (regulation of oxygen supply to working muscles) and Archibald Vivian Hill (production of heat in the muscle and concept of maximal oxygen uptake) pioneered contemporary exercise physiology, both being awarded the Nobel Prize in Physiology or Medicine in 1920 and 1922, respectively.…”

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confidence: 99%