A challenging case of multisystem inflammatory syndrome in children related to coronavirus Disease-19 hospitalized under adult medical service

Alnashri, Huda; AlJohani, Naif I.; Tayeb, Sarah; Rabie, Nada; Albenayan, Eyad; Alharthi, Adil; Samannodi, Mohammed

doi:10.1016/j.idcr.2020.e00957

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…We categorized the reported oral mucosa findings into three subgroups: KWL: Kawasaki‐like syndrome‐associated oral mucosa findings (cracked lips, dry lips, cheilitis with/without erythema of oral mucosa; Table 3). 11,13–16,19–21,25,28,30,32,35–39,41,44,45,48,49 OU: Ulcers in the oral mucosa (aphthous, herpetiform, multiple, single, necrotizing; Table 4). 17,18,22,24,26,27,29,33,40,42,43,46,49,50 M: Miscellaneous group (macular, papular, pustular, bullous, and overlapping cases; Table 5).…”

Section: Resultsmentioning

confidence: 99%

COVID‐19‐related oral mucosa lesions among confirmed SARS‐CoV‐2 patients: a systematic review

et al. 2021

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the virus responsible for coronavirus disease 2019 (COVID‐19), which manifests as a flu‐like respiratory infection affecting multiple organ systems, including the gastrointestinal system, central nervous system, cardiovascular system, skin, and mucosa. In this review, we investigated the literature on specific manifestations of COVID‐19 in the oral mucosa. An online literature search in PubMed, Scopus, Google Scholar, and Medline was conducted to retrieve relevant studies on confirmed COVID‐19 patients with oral mucosa findings published between December 31, 2019, and April 07, 2021. After an independent review by two authors, 39 articles considering 59 laboratory‐confirmed cases of SARS‐CoV‐2 infection were included in the final analysis. The most common finding, reported in 29 patients (43.9%), was Kawasaki‐like syndrome. In addition, oral ulcers including aphthous, hemorrhagic, and necrotic ulcers were reported in 24 patients (36.3%). Other lesions reported included pustules, macules, bullae, maculopapular enanthema, and erythema multiforme‐like lesions. Concomitant skin lesions were present in 60.6% of patients. Fever was reported in 86.2% of patients. Forty‐eight patients (76.1%) were hospitalized. Loss of taste and smell was present in 30.8% of the patients. A comprehensive understanding of the dermatologic manifestations of COVID‐19 can improve and facilitate patient management and referrals.

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Section: Resultsmentioning

confidence: 99%

COVID‐19‐related oral mucosa lesions among confirmed SARS‐CoV‐2 patients: a systematic review

et al. 2021

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“…After removing duplicates, we found 1,510 studies in the database; among which 19 were approved for systematic review, including six case reports [13][14][15][16][17][18], seven case series [7,[19][20][21][22][23][24], and six cross-sectional [8,[25][26][27][28][29] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Ocular Manifestations in Children with COVID-19: Systematic Review and Meta-Analysis

Nasiri

Sharifi

Rahimi

et al. 2022

JoMMID

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Introduction: COVID-19 ocular manifestations commonly occur in adults; however, there is limited data on this manifestation in children. This systematic review and meta-analysis investigated the prevalence of ocular manifestations in children. Methods: We searched PubMed, Scopus, EMBASE, Web of Science, and MedRxiv from December 1, 2019, to February 3, 2021. Two independent reviewers screened the articles, extracted the data, and assessed the quality of the articles. Results: After screening 1,510 articles, 19 were approved and included in the systematic review and meta-analysis. The literature review showed that 89 out of 749 children with COVID-19 had at least one ocular manifestation. The estimated pooled prevalence of ocular manifestations was 8.0% (95% confidence intervals 4.0 -12.0). The most common symptoms were conjunctival discharge (n = 31, 23.1%), conjunctival congestion (n = 21, 16.0%), eye rubbing (n = 19, 14.2%). Conclusion: Ocular manifestations are common in children with COVID-19; one out of 14 infected children shows at least one ocular manifestation. Physicians should pay attention to the ocular manifestations associated with COVID-19 in children. 33. Arias-Peso B, Rendón-Fernández H. Conjunctivitis and COVID-19: The importance of an early detection. Enferm Infecc Microbiol Clin. 2021; 39 (2): 111.

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“…Most reports have mentioned coronary involvement in 0-40% of cases (Table 2) (16,21,24,26,41). Mild coronary artery dilation with z-scores of 2 -2.5 has been reported in most cases.…”

Section: Coronary Involvementmentioning

confidence: 99%

Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection

Ghodsi

Mahmoudabadi

Ghahremani

et al. 2021

Arch Pediatr Infect Dis

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Context: Multisystem inflammatory syndrome in children (MIS-C) is an emerging condition after the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, termed COVID-19. This study aimed to describe the cardiac manifestations of children diagnosed with MIS-C. Evidence Acquisition: This narrative review was conducted by searching the PubMed, Scopus, and Google Scholar databases to review MIS-C cardiac manifestations up to September 30, 2020. The demographic features, past medical history, clinical signs and symptoms, cardiac involvement, and the type of COVID-19 diagnosis confirmation were extracted. Results: In many children, MIS-C seems to be a post-infectious complication of the COVID-19 infection. This syndrome affects multiple organs and has various clinical manifestations mimicking Kawasaki disease. Patients frequently present with persistent fever, kidney injury, gastrointestinal (GI) problems, neurologic symptoms, mucosal changes, conjunctivitis, and cardiac involvement. Children with MIS are more likely to present with hypotension, shock, and cardiac dysfunction, rather than coronary artery abnormalities and arrhythmia. Children with MIS need close observation; some need to be hospitalized, and a few may need a Pediatric Intensive Care Unit (PICU) admission. Treatment currently includes anticoagulants, IV immunoglobulin, and anti-inflammatory drugs. Conclusions: As a novel syndrome associated with SARS-CoV-2 infection, MIS-C is potentially lethal. Cardiac manifestations, including coronary and myocardial involvement, are common and should be carefully identified. With prompt diagnosis and proper treatment, most children will survive, but the outcomes of the disease are unknown, so long-term follow-ups are required.

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A challenging case of multisystem inflammatory syndrome in children related to coronavirus Disease-19 hospitalized under adult medical service

Cited by 8 publications

References 10 publications

COVID‐19‐related oral mucosa lesions among confirmed SARS‐CoV‐2 patients: a systematic review

COVID‐19‐related oral mucosa lesions among confirmed SARS‐CoV‐2 patients: a systematic review

Ocular Manifestations in Children with COVID-19: Systematic Review and Meta-Analysis

Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection

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