A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis

Wu, Ping; Liang, Liang; Yang, Jun; Chen, ChunBao; Nie, ShengQiong

doi:10.21203/rs.3.rs-22835/v1

Cited by 25 publications

(36 citation statements)

References 17 publications

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“…The research of Wu et al(22) indicates that conjunctivitis and eyelid dermatitis may indicate COVID-19, as confirmed by molecular testing, real-time polymerase chain reaction (RT-PCR) on SARS-CoV-2.Collona et al in Italy, it describes frost-like changes in four children aged 5-11 years with mild symptoms of COVID infection, which they explained by a vaso-occlusive phenomenon due to elevated d-dimers (23).Andina et al(24) reported identical changes in Madrid in 22 children aged 6-17 years with moderate symptoms of COVID-19 disease. These atypical manifestations of COVID-19 disease did not require treatment and had a good prognosis(23,24).…”

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confidence: 99%

Coronavirus disease 2019 (COVID-19): a new pediatric challenge

Sporišević¹,

Mesihović-Dinarević

Jogunčić³

et al. 2020

JHSCI

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Coronavirus disease 2019 (COVID 19) is a pandemic disease that is today a global public health problem caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 is a disease of middle and old age, but clinical expression may also be present in childhood. Asymptomatic and mild clinical forms are most often present in persons aged 0-19, but severe clinical forms such as, among others, acute respiratory distress syndrome and multisystem inflammatory syndrome may occur. In addition to presenting the epidemiology, clinical symptomatology of COVID-19, the authors consider certain specifics of COVID-19, that is, possible reasons for the lower incidence of the disease as well as unusual and rare clinical forms of the disease in children. The current activities of health professionals in the supervision of COVID-19 are mainly focused on early detection, isolation and treatment of patients, isolation of contacts, the regular and thorough practice of respiratory hygiene, hand hygiene, and physical distancing. Future efficient and safe vaccination will solve the biggest global medical challenge caused by the new coronavirus in the best possible manner.

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confidence: 99%

Coronavirus disease 2019 (COVID-19): a new pediatric challenge

Sporišević¹,

Mesihović-Dinarević

Jogunčić³

et al. 2020

JHSCI

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“…Laboratory results: Complete blood counts may be normal, 11,14‐16,19,22,26,29,32,39,40,44,48‐50,54,61,79,93,102,165,168 or show either decreased 14,16,19,25,26,29,31,39,40,44,49,55,61,70,93,100,108 or elevated white blood cell counts 11,14,20,22,26,44,47,50,54,60,61,93,99 . Lymphocyte counts may be increased, 15,19,24,26,29,44,60,78,79,82,84,93,96,103,169 or decreased 14,19,22,23,25‐28,31,34,39,44,49,55,70,79,82,84,88,99,100,103,113,116 . Increased C‐reactive protein (CRP), 15,19,22,25,26,28,29,31,40,41,44,47,49,50,56,73,74,77,83,84,88,93,101,103,104 procalcitonin (PCT) 15,22,26,31,44,49,50,56,73,77,84,88,93,99 and lactate dehydrogenase 14,15,22,25,47,81,83,84,93 have been reported.…”

Section: Resultsmentioning

confidence: 99%

Coronavirus global pandemic: An overview of current findings among pediatric patients

Perikleous

Tsalkidis

Bush

et al. 2020

Pediatric Pulmonology

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Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) epidemic has been emerged as a cardinal public health problem. Children have their own specific clinical features; notably, they seem to be escaping the severe respiratory adverse effects. The international scientific community is rapidly carrying out studies, driving to the need to reassess knowledge of the disease and therapeutic strategies. Aim To assess the characteristics of COVID‐19 infected children worldwide of all ages, from neonates to children and adolescents, and how they differ from their adult counterparts. Search Strategy An electronic search in PubMed was conducted, using combinations of the following keywords: coronavirus, SARS‐CoV‐2, COVID‐19, children. The search included all types of articles written in English between January 1, 2019 until August 15, 2020. Results The search identified 266 relevant articles. Children were mainly within family clusters of cases and have relatively milder clinical presentation compared with adults; children were reported to have better outcomes with a significantly lower mortality rate. Cough and fever were the most common symptoms while pneumonia was the cardinal respiratory manifestation of infected children. Laboratory results and thoracic imaging give varying results. Conclusions Children were mainly family cluster cases and usually presented with a mild infection, although cases presented with the multisystem inflammatory syndrome are becoming more apparent. Studies determining why the manifestations of SARS‐CoV‐2 infection are so variable may help to gain a better understanding of the disease and accelerate the development of vaccines and therapies.

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“…The remaining are case reports by Khavandi et al [15], Colavita et al [16], Navel et al [17], Chen et al [18], Cheema et al [19], and Wu et al [20]. These case reports are of patients of various ages, including a child.…”

Section: Summary Of Study Findingsmentioning

confidence: 99%

“…To this end, different research teams have performed reverse transcription polymerase chain reaction (RT-PCR) on ocular samples of tears and conjunctival secretions, and viral cultures. What has been reported is that COVID-19 can be accompanied by conjunctivitis with its attendant symptoms of conjunctival infection, epiphora, itch, discharge, etc., but this remains a relatively rare occurrence compared with the classic respiratory symptoms [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. It is questionable whether the eye is truly a portal of transmission.…”

Section: Introductionmentioning

confidence: 99%

“…What is also unknown is the relative significance of this portal compared with other conventional means like respiratory droplets. Whilst some studies have reported the presence of the virus in ocular samples in eyes without conjunctivitis, others have reported the opposite [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. It is also difficult to ascertain whether the presence of the virus indicates its replication within conjunctival cells or viral shedding due to viraemia.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review of Ocular Involvement of SARS-CoV-2 in Coronavirus Disease 2019

Cheong

2020

Curr Ophthalmol Rep

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Purpose of Review Studies have reported ocular involvement in the coronavirus disease 2019 (COVID-19), with SARS-CoV-2 having been detected in ocular swab samples. This has implicated the eye as a portal of transmission. The aim of this systemic review is to summarise and discuss the current literature regarding ocular involvement of SARS-CoV-2 in COVID-19. Recent Findings In this systematic review, the prevalence of ocular symptoms and signs was low (from 0 to 31.58%) and conjunctivitis was a relatively rare occurrence. The rate of detection of SARS-CoV-2 in the ocular swab samples was low as well and this ranged from 0 to 11.11%. The development of ocular symptoms and signs was not always accompanied by the detection of SARS-CoV-2 in the ocular swab samples. The opposite was described as well. This may reflect issues related to the characteristics of SARS-CoV-2 and of the study design. Nonetheless, the nature of research in a pandemic is that conclusions can change as more information is obtained. Summary Whilst the eye is unlikely to be a main transmission route, we need to consider the possibilities of conjunctivitis as a presenting complaint and of the eye playing a role in the transmission of SARS-CoV-2. Furthermore, we need to take the appropriate precautions in our practice. Further studies are needed to evaluate the viral tropism of SARS-CoV-2 and its role in the eyes.

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A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis

Cited by 25 publications

References 17 publications

Coronavirus disease 2019 (COVID-19): a new pediatric challenge

Coronavirus disease 2019 (COVID-19): a new pediatric challenge

Coronavirus global pandemic: An overview of current findings among pediatric patients

Systematic Review of Ocular Involvement of SARS-CoV-2 in Coronavirus Disease 2019

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