A chitosan based multimodal “soft” hydrogel for rapid hemostasis of non-compressible hemorrhages and its mode of action

Patil, Gokul; Pawar, Rutuja; Jadhav, Sachin; Ghormade, Vandana

doi:10.1016/j.carpta.2022.100237

Cited by 9 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hemocompatibility of the samples was determined as per the procedure described by Patil et al 30 Briefly, freshly drawn sheep blood was centrifuged at 500× g to concentrate the RBCs. The RBC pellet was washed with normal saline until a clear supernatant appeared.…”

Section: Methodsmentioning

confidence: 99%

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Madiwal,

Rajwade

2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Madiwal,

Rajwade

2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

“…After CS contacted the blood, the level of platelet activation markers (platelet factor-4, β-thrombomodulin) increased, and the level of Ca 2+ in platelets was significantly increased, which elevated the expression of glycoprotein IIb/IIIa (glycoprotein II b/IIIa, GP IIb/IIIa) in the platelet membrane. For example, a sodium tripolyphosphate cross-linked CS-based soft hemostatic hydrogel was synthesized by Patil et al [ 74 ]. CS-based hemostatic hydrogel dressing incorporates hemostasis agonists like aluminum chloride, an aggregation enhancer, and silica nanoparticles, a contact activator.…”

Section: Hemostatic Mechanism Of Cs Hydrogelsmentioning

confidence: 99%

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

et al. 2023

View full text Add to dashboard Cite

The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hemostatic hydrogels have frequently been used for hemostasis due to their unique biocompatibility, tunable mechanical properties, injectability, and ease of handling. Moreover, chitosan (CS) absorbs red blood cells and activates platelets to promote hemostasis. Benefiting from these desired properties, the hemostatic application of CS hydrogels is attracting ever-increasing research attention. This paper reviews the recent research progress of CS-based hemostatic hydrogels and their advantageous characteristics compared to traditional hemostatic materials. The effects of the hemostatic mechanism, effects of deacetylation degree, relative molecular mass, and chemical modification on the hemostatic performance of CS hydrogels are summarized. Meanwhile, some typical applications of CS hydrogels are introduced to provide references for the preparation of efficient hemostatic hydrogels. Finally, the future perspectives of CS-based hemostatic hydrogels are presented.

show abstract

“…[ 190 ] Incorporating chitosan into hydrogels can enrich platelets and promote coagulation. [ 191‐194 ] A carbon nanotube‐enhanced quaternary ammonium chitosan‐based cryogel has demonstrated remarkable hemostatic efficacy by exploiting the positive quaternary ammonium group and the amino group of quaternary ammonium chitosan to effectively adsorb platelets to the bleeding site. Carbon nanotubes facilitate the inflow of calcium ions to activate platelets, while the porous structure of the cryogel rapidly absorbs blood to capture platelets (Figure 6).…”

Section: Design Of Bioactive Hydrogel For Hemostasismentioning

confidence: 99%

Bioactive Hydrogels with Pro‐coagulation Effect for Hemostasis^†

Guo,

Ding,

et al. 2023

Chin. J. Chem.

View full text Add to dashboard Cite

Comprehensive SummaryHemostatic hydrogels are widely applied for wound management of damaged tissues, traumatic wounds, and surgical incisions. Some hydrogels composed of bioactive components, including fibrin and thrombin, showed great promise in the clinic due to their good pro‐coagulation effect. Based on the expanding knowledge of cascade catalysis reaction of coagulation and emerging bioactive substances. Recently, massive bioactive hydrogels based on peptides, hemocoagulase, polyphosphate (polyP), etc., have been developed as hemostatic materials. Based on the coagulation process and mechanism, we summarize the role of reported bioactive hydrogels in hemostasis in this review. We conclude the key points in the coagulation process, including activation of coagulation factors, fibrinogen polymerization, etc., then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these points. Finally, we conclude the progress and propose a perspective of bioactive hydrogels with a pro‐coagulation effect for hemostasis.This article is protected by copyright. All rights reserved.

show abstract

A chitosan based multimodal “soft” hydrogel for rapid hemostasis of non-compressible hemorrhages and its mode of action

Cited by 9 publications

References 36 publications

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Bioactive Hydrogels with Pro‐coagulation Effect for Hemostasis^†

Contact Info

Product

Resources

About

A chitosan based multimodal “soft” hydrogel for rapid hemostasis of non-compressible hemorrhages and its mode of action

Cited by 9 publications

References 36 publications

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis

Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Bioactive Hydrogels with Pro‐coagulation Effect for Hemostasis†

Contact Info

Product

Resources

About

Bioactive Hydrogels with Pro‐coagulation Effect for Hemostasis^†