A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro

Wang, Xiaojia; Reece, Sky W.; Scott, Michael R. Van; Brown, Jared M.

doi:10.1016/j.bbi.2010.09.007

Cited by 43 publications

(32 citation statements)

References 50 publications

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“…Consistently, we and others have recently shown that mouse and human MC express a functional molecular clock similar to other peripheral cells, i.e. rhythmic expression of clock genes including Per1, Per2, Cry1, Bmal1, and Clock in murine jejunal MC, in freshly isolated mature as well as in long-term synchronized cultured hiMC (Baumann et al, 2013;Wang et al, 2011). Additionally, some mast cell-specific genes such as Mcpt-5, Mcpt-7, FcεRI ␣-chain and tryptase also exhibited circadian oscillation.…”

Section: Discussionsupporting

confidence: 57%

IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock

Baumann

Feilhauer

Bischoff

et al. 2015

Molecular Immunology

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Section: Discussionsupporting

confidence: 57%

IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock

Baumann

Feilhauer

Bischoff

et al. 2015

Molecular Immunology

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“…Bmal1 deficiency is also linked to reduced osteoblast proliferation in adult mice, although a circadian role here has not been proven . Furthermore, in the complex differentiation processes leading to the development of the immune system, T h 17 T helper cell development is regulated by the circadian factors REV-ERBα and RORγ (RORC -Mouse Genome Informatics) , and circadian cytokine release in vivo and in vitro is likely to influence other immune cell subpopulations (Fortier et al, 2011;Keller et al, 2009;Wang et al, 2011). Finally, in addition to regulating metabolism, multiple circadian clock genes directly regulate the size and differentiation of pancreatic islets (Marcheva et al, 2010).…”

Section: From Tissue Homeostasis To Stem Cells: Circadian Control Of mentioning

confidence: 99%

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

Brown

2014

Development

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A biological 'circadian' clock conveys diurnal regulation upon nearly all aspects of behavior and physiology to optimize them within the framework of the solar day. From digestion to cardiac function and sleep, both cellular and systemic processes show circadian variations that coincide with diurnal need. However, recent research has shown that this same timekeeping mechanism might have been co-opted to optimize other aspects of development and physiology that have no obvious link to the 24 h day. For example, clocks have been suggested to underlie heterogeneity in stem cell populations, to optimize cycles of cell division during wound healing, and to alter immune progenitor differentiation and migration. Here, I review these circadian mechanisms and propose that they could serve as metronomes for a surprising variety of physiologically and medically important functions that far exceed the daily timekeeping roles for which they probably evolved.

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“…Importantly mast cells, eosinophils and basophils display circadian oscillations of clock gene expression as well as circadian gene expression and release of their mediators following IgE-mediated activation (Baumann et al 2013;Wang et al 2011;Ando et al 2015;Baumann et al 2015). Several recent studies have shown that the circadian clock regulated the daily rhythms in IgE/mast cellmediated allergic reactions.…”

Section: There Is a Circadian Variation In Immune Functionmentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro

Cited by 43 publications

References 50 publications

IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock

IgE-dependent activation of human mast cells and fMLP-mediated activation of human eosinophils is controlled by the circadian clock

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

A circadian based inflammatory response – implications for respiratory disease and treatment

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