A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice

Corona, Alberto; Choe, Jane; Muñoz-Castañeda, Rodrigo; Osten, Pavel; Shea, Stephen D.

doi:10.1016/j.celrep.2023.112771

Cited by 7 publications

(2 citation statements)

References 69 publications

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“…Lastly, it is important to mention that the execution of parental behaviors is not solely the province of limbic neurons; it requires the coordinated function of multiple brain regions to process infant cues, make decisions, and formulate and execute motor plans. These processes likely demand higher cognitive functions, and researchers have only recently begun to explore these avenues ( Corona et al, 2023 ). Given the substantial evolutionary expansion of the human frontal cortex, understanding the higher-order functions associated with parental behaviors and the potential interactions between the frontal cortex and limbic circuits during such behaviors are expected to offer valuable insights into human parental behaviors.…”

Section: Perspectivementioning

confidence: 99%

Neural basis for behavioral plasticity during the parental life-stage transition in mice

Miyamichi

2024

Front. Neural Circuits

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Parental care plays a crucial role in the physical and mental well-being of mammalian offspring. Although sexually naïve male mice, as well as certain strains of female mice, display aggression toward pups, they exhibit heightened parental caregiving behaviors as they approach the time of anticipating their offspring. In this Mini Review, I provide a concise overview of the current understanding of distinct limbic neural types and their circuits governing both aggressive and caregiving behaviors toward infant mice. Subsequently, I delve into recent advancements in the understanding of the molecular, cellular, and neural circuit mechanisms that regulate behavioral plasticity during the transition to parenthood, with a specific focus on the sex steroid hormone estrogen and neural hormone oxytocin. Additionally, I explore potential sex-related differences and highlight some critical unanswered questions that warrant further investigation.

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Section: Perspectivementioning

confidence: 99%

Neural basis for behavioral plasticity during the parental life-stage transition in mice

Miyamichi

2024

Front. Neural Circuits

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“…Considering the crucial role of the LC in cognitive processes such as learning and memory and arousal 79 , 80 , we speculate that ascending projections in the LC-ACC may enhance behavioral responses to injury in animals or humans and alert them to dangerous situations. In addition, the circuit from the LC to the ACC played a crucial role in sustained attention and offspring interactions in mice 81 , 82 . In conclusion, LC-ACC noradrenergic neurons may improve visceral pain by regulating multiple behaviors, such as aversion, depression, attention and defense.…”

Section: Accmentioning

confidence: 99%

Neural circuits regulating visceral pain

Chang,

Zhang,

Chen

2024

Commun Biol

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Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers. Neural circuits in the brain encode, store, and transfer pain information across brain regions. In this review, we focus on the anterior cingulate cortex and paraventricular nucleus of the hypothalamus to highlight the progress in identifying the neural circuits involved in visceral pain. We also discuss several neural circuit mechanisms and emphasize the importance of cross-species, multiangle approaches and the identification of specific neurons in determining the neural circuits that control visceral pain.

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Effects of acute inhibition of dopamine β-hydroxylase on neural responses to pups in adult virgin male California mice (Peromyscus californicus)

Acosta,

Hussein,

Saltzman

2024

Behavioural Brain Research

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A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice

Cited by 7 publications

References 69 publications

Neural basis for behavioral plasticity during the parental life-stage transition in mice

Neural basis for behavioral plasticity during the parental life-stage transition in mice

Neural circuits regulating visceral pain

Effects of acute inhibition of dopamine β-hydroxylase on neural responses to pups in adult virgin male California mice (Peromyscus californicus)

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