A circular twist on microRNA regulation

Bezzi, Marco; Guarnerio, Jlenia; Pandolfi, Pier Paolo

doi:10.1038/cr.2017.136

Cited by 53 publications

(44 citation statements)

References 12 publications

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“…RNA transcripts with the same MREs can be competitive in inhibiting the function of miRNAs, thus acting as an RNA sponge to block the binding between miRNAs and their target genes [5,21]. Recent studies have shown that exonic circRNAs can function as ceRNA to regulate the expression of genes by adsorbing miRNAs, thus sponging for miRNAs [18,22,23]. And miRNA sponge effects achieved by circRNA formation are now regarded as a general phenomenon since ciRS-7 (circRNA sponge for miR-7) and sex-determining region Y (Sry, testis-specific circRNA sponge for miR-138) had been discovered by Thomas B. Hansen and his colleagues in 2013 [22].…”

Section: Discussionmentioning

confidence: 99%

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Zhang

Xia

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Discussionmentioning

confidence: 99%

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Zhang

Xia

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…CircRNAs harbor well‐conserved canonical miRNA response elements (MREs), suggesting that some circRNAs act as miRNA sequesters or sponges . A portion of circRNAs are thought to negatively regulate the levels of miRNAs and increase or decrease the expression levels of their corresponding targeted genes (Figure B).…”

Section: Functions Of Circrnasmentioning

confidence: 99%

“…Circular RNAs are generated from lariat-driven circulation or back-splicing events between the splice donor site of a downstream exon and the splice acceptor site of an upstream exon act as miRNA sequesters or sponges. [17][18][19][20] A portion of cir-cRNAs are thought to negatively regulate the levels of miR-NAs and increase or decrease the expression levels of their corresponding targeted genes ( Figure 2B). As a representative circRNA, cerebellar degeneration-related protein 1 antisense (CDR1as) is the sponge of miR-7 in the embryonic zebrafish and has been reported to be related to brain dysfunction and many cancers, such as HCC and gastric cancer.…”

Section: Mirna Sequestrationmentioning

confidence: 99%

Circular RNAs in hepatocellular carcinoma: Functions and implications

Jiang

et al. 2018

Cancer Medicine

109

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At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with distinct properties and diverse pathophysiological functions are being increasingly delineated. CircRNAs play roles at the epigenetic, transcriptional and posttranscriptional regulatory levels. Major studies have focused on their functions as efficient microRNA sponges. The validated number of endogenous circRNAs involved in hepatocellular carcinoma (HCC) continues to increase. Altered circRNA expression is associated with HCC occurrence, invasion, and metastasis. Moreover, the aberrant expression of circRNAs is also significantly related to HCC tumor stage, size, differentiation and metastasis. Because they are exceptionally stable, highly conserved and have tissue‐specific expression patterns, some circRNAs, including hsa_circ_0004018, hsa_circ_0003570, and hsa_circ_0005075, may be potential markers for the diagnosis of HCC. We herein summarize the current knowledge of HCC‐associated circRNAs and present their implications for carcinogenesis and their potential value as diagnostic and prognostic biomarkers. Finally, we discuss the future directions of studies on HCC‐associated circRNAs.

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“…There is increasing evidence that circRNAs play important roles in the regulation of gene expression at the posttranscriptional level [5][6][7]. Accordingly, it has been demonstrated that many circRNAs serve as competing endogenous RNAs to bind with microRNAs (miRNAs) and inhibit the activity and function of the targeted miRNAs [8,9]. With the increasing number of studies on circRNAs, circRNAs have been shown to be involved in the development of several types of diseases, including cancer [10], cardiovascular disease [11], and neurological disorders [12].…”

Section: Introductionmentioning

confidence: 99%

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Zhao

Wang

Ouyang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent studies have demonstrated that circular RNAs (circRNAs) can serve as potential molecular markers for disease diagnosis. However, little is known about their diagnostic potential for oral squamous cell carcinoma (OSCC). This study aimed to determine the expression of circRNAs in the saliva of OSCC patients to identify novel biomarkers for OSCC screening. Methods: Microarray screening of circRNA was performed to identify differentially expressed circRNAs in saliva from 3 OSCC patients compared with 3 healthy controls. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the results, and the association between these confirmed salivary circRNAs and clinicopathological features was analyzed using the chi-squared test. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of the circRNAs identified. Preoperative expression and postoperative expression (1 month after the surgery) of hsa_circ_0001874 and hsa_circ_0001971 was also determined. Results: Our results indicated 12 upregulated and 20 downregulated circRNAs in the saliva from the OSCC patients compared with that from the healthy controls. Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). The combination of hsa_circ_0001874 and hsa_circ_0001971 showed an area under the ROC curve of 0.922 (95% confidence interval, 0.883-0.961; P< 0.001). The risk score based on the combination of hsa_circ_0001874 and hsa_circ_0001971 also discriminated patients with OSCC from patients with oral leukoplakia (P< 0.001). Moreover, the expression levels of salivary hsa_circ_0001874 and hsa_circ_0001971 were clearly decreased in the postoperative samples compared with preoperative samples (P< 0.001). Conclusions: This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC.

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A circular twist on microRNA regulation

Cited by 53 publications

References 12 publications

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Circular RNAs in hepatocellular carcinoma: Functions and implications

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

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