2024
DOI: 10.1038/s41467-024-51354-1
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A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Sarah E. Conduit,
Wayne Pearce,
Amandeep Bhamra
et al.

Abstract: Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly. Genetic PI3Kα-hyperactivation, as observed in PIK3CA-related overgrowth … Show more

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