A Clinical Comparative Study of Piperacillin and Sulbactam/Ampicillin in Patients with Community-Acquired Bacterial Pneumonia

Seki, Masafumi; Higashiyama, Yasuhito; Imamura, Yoshifumi; Nakamura, Shigeki; Kurihara, Shintaro; Izumikawa, Koichi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Yanagihara, Katsunori; Tashiro, Takayoshi; Kohno, Shigeru

doi:10.2169/internalmedicine.48.1614

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…However, we underscore rational use of these antibiotics to prevent emergence of resistant strains of H. influenzae and other bacteria, including Pseudomonas aeruginosa [18] . For these reasons, piperacillin may be an appropriate first choice to treat CAP during influenza season [19] .…”

Section: Discussionmentioning

confidence: 99%

Association of influenza with severe pneumonia/empyema in the community, hospital, and healthcare-associated setting

Seki

Fuke

Oikawa

et al. 2016

Respiratory Medicine Case Reports

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We presented three cases of influenza-related severe pneumonia/empyema that occurred in one season.Case 1A 76-year-old diabetic man, developed empyema as a result of severe community-acquired pneumonia (CAP) secondary to Haemophilus influenzae, as confirmed on sputum culture. Nasal swab was positive for influenza A antigen. After drainage of empyema, intravenous peramivir and piperacillin/tazobactam were administered for 3 days and 2 weeks, respectively, followed by oral levofloxacin for 2 weeks. Eventually, he recovered. In this case, the isolated H. influenzae was non-typeable and negative for beta-lactamase.Case 2A 55-year-old man with suspected cerebral infarction and diabetes mellitus (DM) developed severe pneumonia/empyema as result of hospital-acquired pneumonia (HAP). Although influenza A antigen was detected, no bacterium was isolated from the sputum, blood, or pleural effusion. He showed severe hypoxia, but recovered after administration of peramivir and levofloxacin with prednisolone for 5 days and 2 weeks, respectively.Case 3A 76-year-old woman with heart failure and DM was followed-up on an outpatient basis and was under nursing home care for four months. Subsequently, she developed pneumonia and was admitted to our hospital; influenza antigen was isolated from nasal swab. Healthcare-associated pneumonia (HCAP)/empyema were diagnosed and were effectively treated with peramivir and levofloxacin for 4 days and 1 week, respectively.In diabetic patients, influenza virus may possibly accelerate pneumonia/empyema due to bacterial coinfection. Although non-typeable H. influenzae is a rare causative pathogen of empyema, it can be expected as a result of “pathogen shift” due to the increased use of the H. influenzae type b vaccine in Japan.

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Section: Discussionmentioning

confidence: 99%

Association of influenza with severe pneumonia/empyema in the community, hospital, and healthcare-associated setting

Seki

Fuke

Oikawa

et al. 2016

Respiratory Medicine Case Reports

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“…The general clinical efficiency of piperacillin therapy in these patients was similar to that of ampicillin-sulbactam therapy. The previous study by Seki et al concluded that piperacillin was effective in the treatment of pneumonia and proposed piperacillin as a first-line treatment for community-acquired pneumonia [ 36 ]. From the results of our study, piperacillin cannot be recommended as a first-line treatment for patients with pneumonia caused by Haemophilus species because of its relatively high resistance rate and lower sensitivity rate according to our susceptibility testing results.…”

Section: Discussionmentioning

confidence: 99%

No development of ciprofloxacin resistance in the Haemophilus species associated with pneumonia over a 10-year study

2015

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BackgroundThe widespread overuse of antibiotics promotes the development of antibiotic resistance in bacteria, which can cause severe illness and constitutes a major public health concern. Haemophilus species are a common cause of community- and nosocomial-acquired pneumonia. The antibiotic resistance of these Gram-negative bacteria can be prevented through the reduction of unnecessary antibiotic prescriptions, the correct use of antibiotics, and good hygiene and infection control. This article examines, retrospectively, antibiotic resistance in patients with community- and nosocomial-acquired pneumonia caused by Haemophilus species.MethodsThe demographic, clinical, and laboratory data of all patients with community- and nosocomial-acquired pneumonia caused by Haemophilus species were collected from the hospital charts at the HELIOS Clinic, Witten/Herdecke University, Wuppertal, Germany, within a study period from 2004 to 2014. Antimicrobial susceptibility testing was performed for the different antibiotics that have been consistently used in the treatment of patients with pneumonia caused by Haemophilus species.ResultsDuring the study period of January 1, 2004, to August 12, 2014, 82 patients were identified with community- and nosocomial-acquired pneumonia affected by Haemophilus species. These patients had a mean age of 63.8 ± 15.5 (60 [73.2 %, 95 % CI 63.6 %–82.8 %] males and 22 [26.8 %, 95 % CI 17.2 %–36.4 %] females). Haemophilus species had a high resistance rate to erythromycin (38.3 %), ampicillin (24.4 %), piperacillin (20.8 %), cefuroxime (8.5 %), ampicillin-sulbactam (7.3 %), piperacillin-sulbactam (4.3 %), piperacillin-tazobactam (2.5 %), cefotaxime (2.5 %), and levofloxacin (1.6 %). In contrast, they were not resistant to ciprofloxacin in patients with pneumonia (P = 0.016).ConclusionHaemophilus species were resistant to many of the typically used antibiotics. Resistance toward ciprofloxacin was not detected in patients with pneumonia caused by Haemophilus species.

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“…The search for RCTs yielded 5,495 titles. After applying inclusion and exclusion criteria, 43 RCTs were included in the final analysis (Figure ): two trials of CAP‐C; three of mixed CAP‐C and CAP‐H, 20 of CAP‐H, two of mixed CAP‐H and HCAP, three of HCAP, six of HAP, five of VAP, and two of HAP and VAP . Two CAP‐H trials targeted a priori an elderly population …”

Section: Resultsmentioning

confidence: 99%

Participation of Elderly Adults in Randomized Controlled Trials Addressing Antibiotic Treatment of Pneumonia

Avni

Shiver-Ofer

Leibovici

et al. 2015

J American Geriatrics Society

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A Clinical Comparative Study of Piperacillin and Sulbactam/Ampicillin in Patients with Community-Acquired Bacterial Pneumonia

Abstract: Objective

Cited by 6 publications

References 23 publications

Association of influenza with severe pneumonia/empyema in the community, hospital, and healthcare-associated setting

Association of influenza with severe pneumonia/empyema in the community, hospital, and healthcare-associated setting

No development of ciprofloxacin resistance in the Haemophilus species associated with pneumonia over a 10-year study

Participation of Elderly Adults in Randomized Controlled Trials Addressing Antibiotic Treatment of Pneumonia

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