A Clinical Conundrum: Chronic Cervicitis

Hester, Erin E.; Middleman, Amy B.

doi:10.1016/j.jpag.2018.12.004

Cited by 8 publications

(6 citation statements)

References 4 publications

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“…The majority of persistent cases of cervicitis are not caused by reinfection with C. trachomatis or N. gonorrhoeae; other factors might be involved (e.g., persistent abnormality of vaginal flora, M. genitalium, douching or exposure to other types of chemical irritants, dysplasia, or idiopathic inflammation in the zone of ectopy). Available data do not indicate an association between group B streptococcus colonization and cervicitis ( 773 , 774 ). No specific evidence exists for a role for Ureaplasma parvum or Ureaplasma urealyticum in cervicitis ( 707 , 761 , 765 , 775 , 776 ).…”

Section: Diseases Characterized By Urethritis and Cervicitismentioning

confidence: 99%

Sexually Transmitted Infections Treatment Guidelines, 2021

Workowski¹,

Bachmann²,

Chan³

et al. 2021

MMWR Recomm. Rep.

1,732

2,621

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These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Physicians and other health care providers can use these guidelines to assist in prevention and treatment of STIs. BOX 1. The Five P's approach for health care providers obtaining sexual histories: partners, practices, protection from sexually transmitted infections, past history of sexually transmitted infections, and pregnancy intention Additional information about external condoms is available at https://www.cdc.gov/condomeffectiveness. Internal CondomsCondoms for internal vaginal use, also known as female condoms, are available worldwide (e.g., the FC2 Female Condom, Reddy condom, Cupid female condom, and Woman's condom) (31,32). Use of internal condoms can provide protection from acquisition and transmission of STIs, although data are limited. Internal condoms are more costly compared with external condoms; however, they offer the advantage of being controlled by the receptive partner as an STI and HIV prevention method, and the newer versions might be acceptable to all persons. Although the internal condom also has been used during receptive anal intercourse, efficacy associated with this practice remains unknown (33). Additional information about the internal condom is available at http://www.ashasexualhealth. org/pdfs/Male_and_Female_Condoms.pdf. Cervical DiaphragmsIn observational studies, diaphragm use has been demonstrated to protect against cervical gonorrhea, chlamydia, and trichomoniasis (34). However, a trial examining the effect of a diaphragm plus lubricant on HIV acquisition among women in Africa reported no additional protective effect when compared with the use of male condoms alone. Likewise, no difference by study arm in the rate of acquisition of chlamydia, gonorrhea, or herpes occurred (35,36). Diaphragms should not be relied on as the sole source of protection against HIV and other STIs.

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Section: Diseases Characterized By Urethritis and Cervicitismentioning

confidence: 99%

Sexually Transmitted Infections Treatment Guidelines, 2021

Workowski¹,

Bachmann²,

Chan³

et al. 2021

MMWR Recomm. Rep.

1,732

2,621

View full text Add to dashboard Cite

show abstract

“…It is considered to be related to wit sexuallytransmitted pathogens with rates as high as 30-45% in those populations like cytomegalovirus [6]. While less than half of cervicitis cases are thought to be due to Neisseria gonorrhoeae and Chlamydia infections, the causes of the remainder which are known as non-gonococal, non-chlamydial cervicitis or non-specific cervicitis are still unknown [7]. There are also variable pathogenic contributions of Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, Herpes simplex, Cytomegalovirus, Adenovirus as well as Trichomonas vaginalis and Toxoplasmosis [8].…”

Section: Introductionmentioning

confidence: 99%

Mutation Occurrence in Ptgs2gene Sequence in Cervicitis Due to Toxoplasmosis and Cytomegalovirus Infections

Kamel¹

2023

MINAR Journal

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In this study, venous blood samples were obtained from 100 women with Cytomegalovirus infection whose ages ranged from 18 to 60 years, and 100 healthy women as a control group. The study was conducted at Al-Elwiya teaching hospital in Baghdad city during the period from 1st November 2021 to 15th June 2022. the distrbution of study groups according to age revealed a significant difference (P=0.01) in the cervicitis patient group (34.43±11.89) in comparison with the control group (39.05±13.53). The distrbution of study groups according to the residency showed that residents of rural areas were 51(51.0%) in comparison with the control group and residents of urban areas were 49(49.0%), while the healthy control group was 51(51.0%) with no significant differences (P=0.088). A highly significant differences were bserved between the mean levels of tumor marker Ca125 in patients (25.5±0.71) in comparison with the healthy controls (19.40±0.68), and between mean levels of Ca15.3 (20.80±0.74) and the healthy control group (18.34±0.77). In addition, the mean levels of CRP was (88.06±5.88) versus the controls (6.73±0.12), with a highly significant differences (P<0.001). Also, no significant differences were seen between mean levels of Ca19.9 marker (19.62±0.79) and the control group (19.21±0.71) (P= 0.7). The distribution of polymorphism according to complete blood picture was shown in table (3) .The mean lymphocyte count was 12(60%), while there was a decrease in Hb levels 3(15%), PCV value 4(20%) and Nuetrophil count 2(10%), with no significant differences. there was no mutation occured in the analysis of rs888160762 SNP of PTGS2 gene, but showed a mutation occured in the analysis of rs20417 SNP of PTGS2 gene using Sanger sequencing. The single “C” peak indicates C homozygous alleles, while the presence of “G” and “C” peaks indicates G/C heterozygous alleles

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“…Chronic cervicitis is defined as the inflammation of the cervix. Patients with chronic cervicitis are very common ( Woods et al, 2011 ; Hester and Middleman, 2019 ). Early screening for cervix precancerous lesions is essential to prevent or treat cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Chronic Cervicitis and Cervical Cancer Detection Based on Deep Learning of Colposcopy Images Toward Translational Pharmacology

Huang

Sun

et al. 2022

Front. Pharmacol.

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With the rapid development of deep learning, automatic image recognition is widely used in medical development. In this study, a deep learning convolutional neural network model was developed to recognize and classify chronic cervicitis and cervical cancer. A total of 10,012 colposcopy images of 1,081 patients from Hunan Provincial People’s Hospital in China were recorded. Five different colposcopy image features of the cervix including chronic cervicitis, intraepithelial lesions, cancer, polypus, and free hyperplastic squamous epithelial tissue were extracted to be applied in our deep learning network convolutional neural network model. However, the result showed a low accuracy (42.16%) due to computer misrecognition of chronic cervicitis, intraepithelial lesions, and free hyperplastic squamous epithelial tissue with high similarity. To optimize this model, we selected two significant feature images: chronic cervicitis and cervical cancer to input into a deep learning network. The result indicates high accuracy and robustness with an accuracy of 95.19%, which can be applied to detect whether the patient has chronic cervicitis or cervical cancer based on the patient’s colposcopy images.

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A Clinical Conundrum: Chronic Cervicitis

Cited by 8 publications

References 4 publications

Sexually Transmitted Infections Treatment Guidelines, 2021

Sexually Transmitted Infections Treatment Guidelines, 2021

Mutation Occurrence in Ptgs2gene Sequence in Cervicitis Due to Toxoplasmosis and Cytomegalovirus Infections

Chronic Cervicitis and Cervical Cancer Detection Based on Deep Learning of Colposcopy Images Toward Translational Pharmacology

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