A clinical guide to endodontics – update part 2

Carrotte, P; Waterhouse, Paula

doi:10.1038/sj.bdj.2009.56

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…FC showed two cases of pathologic mobility one of them at 6 months and the other at 12 months follow up. These results were supported by Farsi et al (40) and Carrotte and Waterhouse (41) who explained this unfavorable response on the bases that when FC comes in direct contact with vital pulp for five minuets , this time is very short to produce complete fixation leaving the pulp in a state of chronic inflammation which results in pathologic mobility. Waterhouse et al (42) and Vargas and Packham (43) explained the occurrence of pathologic mobility due to the chronic irritation of the pulp tissues from the eugenol content of the freshly prepared zinc oxide eugenol paste which may result in internal and or external root resorption.…”

Section: Discussionmentioning

confidence: 55%

Clinical And Radiographic Evaluation Of Biodentine Versus Formocresol In Vital Pulpotomy Of Primary Molars (A Randomized Control Clinical Trial)

Elbardissy

Sayed

2019

Egyptian Dental Journal

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Background:The main objective of pulp therapy is to preserve the integrity and health of the teeth and their supporting tissues, as well as to maintain the pulp vitality. Formocresol (FC) is that fixing agent which is considered as gold standard and used as pulpotomy medicament for primary teeth for decades. Several concerns had been reported about the use of FC. These concerns push new medicaments to be used for pulpotomy purposes. Among these medicaments is Biodentine (BD). Aim of the study:To compare FC and BD clinically and radiographically when used for pulpotomy of vital primary molars.Study Design : A randomized control clinical trial (split mouth and double blind) was conducted on 43 (4-6 years-old) children with decayed vital mandibular primary molars which were treated by pulpotomy using both medicaments . All treated teeth were followed for one year (at 3, 6, 9 and 12 months clinically and at 6 and 12 months radiographically).Results: BD showed 100% clinical and radiographic success at all follow up timing, however FC showed 85.4% and 78% radiographic success at 6 and 12 months follow up period . By clinical evaluation FC showed 95.1% success at the end of follow up period with no significant difference.Conclusions: BD as a pulpotomy medicament showed 100% clinical and radiographic success with no statistically significant difference with FC clinically. However a statistically significant difference was recorded between both medicaments regarding their radiographic success rate where BD was superior.

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Section: Discussionmentioning

confidence: 55%

Clinical And Radiographic Evaluation Of Biodentine Versus Formocresol In Vital Pulpotomy Of Primary Molars (A Randomized Control Clinical Trial)

Elbardissy

Sayed

2019

Egyptian Dental Journal

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“…). Conversely, nonvital pulp therapy involves the removal of irreversibly inflamed or necrotic pulp tissue, cleaning of the root canals and filling with a resorbable paste to restore and/or maintain the health of the periradicular tissues until exfoliation (Carrotte & Waterhouse ). Several methods have been developed to preserve pulp vitality in primary teeth with deep caries such as indirect or direct pulp capping and vital pulpotomy (Kisby ).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth

et al. 2017

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Aims To investigate the cytotoxicity and bioactivity of several pulpotomy materials: Biodentine (Septodont, Saint-Maur-des-Fosses, France) MTA (Angelus, Londrina, PR, Brazil), Theracal LC (Bisco Inc., Schamburg, IL, USA) and IRM (Dentsply DeTrey GmbH, Konstanz, Germany), after contact with stem cells isolated from human exfoliated primary teeth (SHEDs). Methodology SHEDs were cultured in the presence of the eluates of various pulpotomy materials for 24, 48 and 72 h. Cell viability was determined by mitochondrial dehydrogenase enzymatic (MTT) assay. Apoptosis and changes in cell phenotype were evaluated by flow cytometry. Also, an in vitro scratch wound-healing assay was used to determine their effects on cell migration. To assess cell morphology and attachment to the different pulpotomy materials, SHEDs were directly seeded onto the material surfaces and analysed by scanning electron microscopy (SEM).Finally, the deposition of a calcified matrix in presence of these materials was verified by Alizarin Red staining. Statistical analysis was performed with analysis of variance and Bonferroni or Tukey post-test (a = 0.05). Results Cell viability in the presence of Biodentine eluates was significantly higher to that obtained using complete medium alone (control; P < 0.01) and was also significantly higher than using MTA Angelus from 48 h of incubation (P < 0.01). However, Theracal LC and IRM were associated with low rates of cell viability (P < 0.001). Similar results were obtained in an apoptosis assay. In addition, SHEDs maintained their mesenchymal phenotype in all conditions although their capacity to migrate was higher in the presence of Biodentine. SEM studies revealed a suitable proliferation rate, cell spreading and attachment, especially when using Biodentine and MTA Angelus discs. Finally, Biodentine eluates significantly induced calcified matrix deposition from 7 days of culture (P < 0.01). Conclusions Biodentine exhibited better cytocompatibility and bioactivity than MTA Angelus, Theracal LC and IRM.

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“…18 The treated molars were isolated with rubber dam to ensure adequate isolation which is necessary to prevent salivary and bacterial contamination. 19 Data were referred to the statistician in the form of labelled groups to avoid information bias.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiographic Evaluation of Vital Pulpotomy in Primary Molar using Antioxidant Mix as a Novel Pulpotomy Medication versus Formcresol: A Randomized Clinical Trial.

Yousry

Latif

Gawad

2021

Advanced Dental Journal

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Background: Formocresol (FC) reported high success rates when used in pulpotomy of primary molars , however many concerns have been raised regarding its mutagenicity, carcinogenicity, its local toxicity, Objectives: to assess the success rates of Antioxidant mix and FC, used as pulpotopmy agents in vital primary molars, both clinically and radiographically. Materials and Methods: Randomized clinical trial. Fifty-two (52) primary mandibular molars in thirtyfive (35) children ranging in age from four to eight years were included in the study. Molars were divided into two equal groups (n= 26), Antioxidant mix (group 1) & FC (group 2) as a pulp medicament. All pulpotomized teeth were finally restored with stainless steel crowns. Subjects were monitored clinically & radiographically at three, six and nine months. Results: The clinical and radiographic success rates of Antioxidant mix & FC by the end of the nine months were [(84.6 & 46.2%) & (88.4 & 84.6%)] respectively. Conclusion: Antioxidant mix may not provide a reliable biological method for vital pulp therapy in primary molars.

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A clinical guide to endodontics – update part 2

Abstract: For debate and development of a position WATCH COMMITTEEThe carcinogenicity of formaldehyde Issue 1. To obtain a WATCH position on the strength of evidence that formaldehyde has caused cancer in humans.

Cited by 9 publications

References 20 publications

Clinical And Radiographic Evaluation Of Biodentine Versus Formocresol In Vital Pulpotomy Of Primary Molars (A Randomized Control Clinical Trial)

Clinical And Radiographic Evaluation Of Biodentine Versus Formocresol In Vital Pulpotomy Of Primary Molars (A Randomized Control Clinical Trial)

Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth

Clinical and Radiographic Evaluation of Vital Pulpotomy in Primary Molar using Antioxidant Mix as a Novel Pulpotomy Medication versus Formcresol: A Randomized Clinical Trial.

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