A clinical study of meibomian gland dysfunction in patients with diabetes

P, Shamsheer R; Arunachalam, Cynthia

doi:10.4103/0974-9233.167827

Cited by 43 publications

(12 citation statements)

References 14 publications

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“…We compared meibographic findings in the 4 groups, and a significant difference in the meiboscore was found between the control patients and the over 10 years diabetic patients. This was consistent with previous findings [ 23 , 24 ] where diabetes was associated with MGD. Our data showed that duration of diabetes was closely related to the severity of meibomian gland abnormality (as reflected by the meiboscore, which indicates meibomian gland loss).…”

Section: Discussionsupporting

confidence: 94%

Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

Zhao

Liu

et al. 2018

Journal of Ophthalmology

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Purpose To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). Results The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P < 0.05). Conclusion Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.

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Section: Discussionsupporting

confidence: 94%

Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

Zhao

Liu

et al. 2018

Journal of Ophthalmology

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“…Accordingly, several studies documented that diabetes mellitus was associated with MGD [22, 33]. Surprisingly, we found no association of MGL with systemic diseases such as diabetes mellitus, after adjusting for age and sex.…”

Section: Discussioncontrasting

confidence: 71%

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Machalińska

Zakrzewska

Safranow

et al. 2016

Journal of Ophthalmology

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Purpose. The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. Methods. We included into the study 91 healthy volunteers between the ages of 20 and 77 years. We analyzed meibomian gland morphology, function, and lid margin alterations. We correlated our findings with self-reported ocular symptoms, systemic medical history, lifestyle factors, and tear film abnormalities. Results. We observed that a high ocular surface disease index, a history of either chalazion or hordeolum, experience of puffy eyelids upon waking, and foreign body sensation all appeared to be predictors of an abnormal meiboscore after adjusting for age and sex (p = 0.0007; p = 0.001; p = 0.02; p = 0.001, resp.). Multivariate logistic regression model including age and sex showed that there were three independent predictors of abnormal meiboscore: older age (OR = 1.03, 95% CI = 1.01–1.04 per year, p = 0.006), postmenopausal hormone therapy (OR = 4.98, 95% CI = 1.52–16.30, p = 0.007), and the use of antiallergy drugs (OR = 5.85, 95% CI = 2.18–15.72, p = 0.0004). Conclusion. Our findings extend current knowledge on the pathophysiology of MGL.

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“…These structures regulate tear secretion and formation of the tear film to maintain the integrity and normal function of the tear film. Abnormality in any part of ocular surface tissues could result in xerophthalmia (Malik et al, 2013;Shamsheer and Arunachalam, 2015). Diabetic patients often show incomplete conjunctival epithelium, which leads to difficulties in tear film attachment and a reduction in the numbers of goblet cells.…”

Section: Discussionmentioning

confidence: 99%

Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia

Wu¹,

Dai²,

Xu³

et al. 2016

Genet. Mol. Res.

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Diabetes-induced xerophthalmia is a general metabolic disorder with high incidence and increased treatment difficulty. Our study aimed to explore the combined effect of traditional Chinese and Western medicines on diabetes-associated xerophthalmia. We recruited 60 diabetic xerophthalmia patients, and randomly assigned them to either the control (Western medicine treatment) or the experimental (combined treatment of traditional Chinese medicine and Western medicine) groups. Pre-treatment and post-treatment analyses were performed to assess the combined therapeutic effect of traditional Chinese and Western medicine on xerophthalmia-associated indicators. We found that the experimental group expressed reduced levels of IL-1, IL-8, and TNF-α (P < 0.05) as compared to the control group. Furthermore, the experimental group showed higher treatment efficacy as compared to the control group (85.00 vs 51.67% Z = 22.244, P < 0.05). In addition, break-up time (t = 20.582, P < 0.05) and tear section (t = 23.082, P < 0.05) was increased in the experimental group as compared to the controls. Lastly, it was found that the combined treatment of traditional Chinese and Western medicine effectively reduced corneal injuries, as indicated by reduced fluorescein staining. This study suggested that a combination treatment consisting of both traditional Chinese and Western medicines may be effective against xerophthalmia in diabetes, and that inflammatory factors are potential biomarkers to examine the treatment efficacy.

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A clinical study of meibomian gland dysfunction in patients with diabetes

Cited by 43 publications

References 14 publications

Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population

Combined effect of traditional Chinese and Western medicine on inflammatory factors in patients with diabetes-induced xerophthalmia

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